Histamine 4 receptor plays an important role in auto-antibody-induced arthritis
| العنوان: | Histamine 4 receptor plays an important role in auto-antibody-induced arthritis |
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| المؤلفون: | David Frommholz, Rolf Bräuer, Harald Illges, Mieczyslaw Gajda, Elisa Nent |
| المصدر: | International Immunology. 25:437-443 |
| بيانات النشر: | Oxford University Press (OUP), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Immunology, Histamine Antagonists, Arthritis, Mice, Transgenic, Histamine H1 receptor, Pharmacology, Autoimmune Diseases, Receptors, G-Protein-Coupled, Arthritis, Rheumatoid, Mice, chemistry.chemical_compound, Histamine receptor, Mice, Inbred NOD, medicine, Animals, Immunology and Allergy, Histamine H4 receptor, Clozapine, Autoantibodies, Receptors, Histamine H4, Thioperamide, business.industry, Glucose-6-Phosphate Isomerase, Degranulation, General Medicine, Mast cell, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, chemistry, Receptors, Histamine, business, Histamine, medicine.drug |
| الوصف: | Rheumatoid arthritis is a widespread autoimmune disease. In the murine K/B×N arthritis model, anti-GPI (anti-glucose 6-phosphate isomerase) antibodies lead to the formation of immune complexes. In the course of pathogenesis, these complexes activate the immune system and induce degranulation of mast cells, which are essential in this model of rheumatoid arthritis. A major mediator in mast cell granules is histamine, which is proven to be indispensable for joint inflammation in K/B×N mice. Histamine is known to bind to four different receptors (HR1–4), which have different expression profiles and exert a variety of different functions, including activation of the immune system. To analyze the contribution of the different histamine receptors, we employed histamine receptor antagonists (cetirizine, ranitidine, thioperamide and clozapine) blocking the receptors in C57BL/6 mice. Arthritis was induced via K/B×N serum injection. The results demonstrated that mice treated with all four histamine receptor antagonists simultaneously showed no arthritic symptoms, while positive control mice injected with K/B×N serum and vehicle suffered from severe symptoms. When antagonists specific for HR1–4 were applied individually, only the HR4 antagonist clozapine could protect mice from arthritis, reflecting its expression and functionality in the immune system. |
| تدمد: | 1460-2377 0953-8178 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f025cc8aa253a5ce8f7e9d42e02146 https://doi.org/10.1093/intimm/dxt008 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....90f025cc8aa253a5ce8f7e9d42e02146 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602377 09538178 |
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