Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil
| العنوان: | Successful outcome after a single endoscopic fecal microbiota transplantation in a Shiba dog with non-responsive enteropathy during the treatment with chlorambucil |
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| المؤلفون: | Kaho Takahashi, Junpei Kimura, Marin Hirokawa, Koji Sugita, Genki Ishihara, Masaki Miyajima, Hirotaka Kondo, Yasuyoshi Matsuda, Ayaka Shima, Keitaro Ohmori |
| المصدر: | The Journal of Veterinary Medical Science |
| بيانات النشر: | The Japanese Society of Veterinary Science, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Diarrhea, Male, medicine.medical_specialty, Anemia, Gastroenterology, Lethargy, Feces, Dogs, Internal medicine, hemic and lymphatic diseases, medicine, Internal Medicine, Animals, Enteropathy, Hypoalbuminemia, Leukocytosis, Dog Diseases, General Veterinary, Chlorambucil, business.industry, fecal microbiota transplantation, hypoalbuminemia, dysbiosis, Shiba dog, medicine.disease, Note, Intestinal Diseases, Treatment Outcome, Vomiting, non-responsive enteropathy, medicine.symptom, business, Dysbiosis, medicine.drug |
| الوصف: | A 7-year 6-month-old, castrated male Shiba dog presented with a 1-month history of lethargy, anorexia, vomiting, and frequent watery diarrhea. Weight loss, hypoalbuminemia, anemia, and leukocytosis were detected at the first visit. The dog was diagnosed with non-responsive enteropathy (NRE) based on clinical and histopathological examinations. Since the dog did not respond to the immunosuppressive drugs, fecal microbiota transplantation (FMT) was performed during the treatment with chlorambucil. A single endoscopic FMT into the cecum and colon drastically recovered clinical signs and clinicopathological abnormalities and corrected dysbiosis in the dog. No recurrence or adverse events were observed. The present case report suggests that FMT, possibly together with chlorambucil, might be a treatment option for NRE in Shiba dogs that have poorer prognosis compared with other dog breeds. |
| اللغة: | English |
| تدمد: | 1347-7439 0916-7250 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f85667b5ddcc48e6bf02da20a477a3 http://europepmc.org/articles/PMC8267193 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....90f85667b5ddcc48e6bf02da20a477a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13477439 09167250 |
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