Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment
| العنوان: | Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment |
|---|---|
| المؤلفون: | Elker Lene Santos de Lima, Ana Lúcia Coutinho Domingues, Saulo Gomes de Oliveira, Ilana Brito Ferraz de Souza, Paula Carolina Valença Silva, Taynan da Silva Constantino, Maria Tereza Cartaxo Muniz |
| المصدر: | Revista da Sociedade Brasileira de Medicina Tropical, Volume: 54, Article number: e01452020, Published: 21 DEC 2020 Revista da Sociedade Brasileira de Medicina Tropical, Vol 54 (2020) Revista da Sociedade Brasileira de Medicina Tropical |
| بيانات النشر: | Sociedade Brasileira de Medicina Tropical - SBMT, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Liver Cirrhosis, 0301 basic medicine, Microbiology (medical), Genotype, Short Communication, RC955-962, 030106 microbiology, 030231 tropical medicine, Population, Schistosomiasis, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, Exon, 0302 clinical medicine, Polymorphism (computer science), Arctic medicine. Tropical medicine, medicine, Animals, Humans, Genetic Predisposition to Disease, Allele, education, Gene, Retrospective Studies, Mannan-binding lectin, education.field_of_study, Mannose-binding lectin, Polymorphism, Genetic, Exons, Periportal fibrosis, biology.organism_classification, medicine.disease, Molecular biology, Infectious Diseases, Parasitology, Schistosoma mansoni, Brazil |
| الوصف: | INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni, who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population. |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9123f990b2a88561e792eae41dd9e278 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100608&lng=en&tlng=en |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9123f990b2a88561e792eae41dd9e278 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |