A facile strategy for the high yielding, quantitative conversion of polyglycol end-groups to amines
| العنوان: | A facile strategy for the high yielding, quantitative conversion of polyglycol end-groups to amines |
|---|---|
| المؤلفون: | Jie Yan, Anton Blencowe, Paula Facal Marina |
| المساهمون: | Yan, Jie, Marina, Paula Facal, Blencowe, Anton |
| المصدر: | Polymers, Vol 13, Iss 1403, p 1403 (2021) Polymers |
| بيانات النشر: | Switzerland : MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | chemistry.chemical_classification, Polymers and Plastics, poly(ethylene glycol), Zn-mediated reduction, Communication, amino end-group, polyglycol, Organic chemistry, General Chemistry, Polymer, Nuclear magnetic resonance spectroscopy, Polyvinyl alcohol, Combinatorial chemistry, chemistry.chemical_compound, QD241-441, chemistry, Yield (chemistry), Reagent, endgroup transformations, Copolymer, Ammonium chloride, Ethylene glycol, end-group transformations |
| الوصف: | Amino end-group functionalised polyglycols are important intermediates in the synthesis of sophisticated polymeric architectures and biomaterials. Herein, we report a facile strategy for the end-group conversion of hydroxyl-terminated polyglycols to amino-terminated polyglycols in high isolated yields and with excellent end-group fidelity. Following traditional conversion of polyglycol hydroxyl end-groups to azides via the corresponding mesylate, reduction with zinc in the presence of ammonium chloride afforded a range of amino end-group functionalised poly(ethylene glycol) and poly(propylene glycol) homopolymers and copolymers with isolated yields of 82–99% and end-group conversions of >99% as determined by NMR spectroscopy and MALDI ToF MS. Furthermore, this process is applicable to a sequential reagent addition approach without intermediate polymer isolation steps with only a slight reduction in yield and end-group conversion (95%). Importantly, a simple work-up procedure provides access to high purity polyglycols without contamination from other reagents. Refereed/Peer-reviewed |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9168f36be559a8371e827a64ca26855a https://hdl.handle.net/11541.2/147352 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9168f36be559a8371e827a64ca26855a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |