Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects
| العنوان: | Interaction of allopurinol and hydrochlorothiazide during prolonged oral administration of both drugs in normal subjects |
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| المؤلفون: | R Landthaler, Ingeborg Walter-Sack, A. Ittensohn, J. X. de Vries, N. Zöllner, W. Löffler, Andreas Voss |
| المصدر: | The Clinical Investigator. 72:1076-1081 |
| بيانات النشر: | Springer Science and Business Media LLC, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Allopurinol, medicine.medical_treatment, Cmax, Administration, Oral, Oxypurinol, Pharmacology, chemistry.chemical_compound, Hydrochlorothiazide, Pharmacokinetics, Reference Values, Oral administration, Internal medicine, Drug Discovery, Humans, Medicine, Drug Interactions, Genetics (clinical), Thiazide, Oxipurinol, business.industry, General Medicine, Endocrinology, chemistry, Molecular Medicine, Diuretic, business, medicine.drug |
| الوصف: | The kinetics of allopurinol and hydrochlorothiazide were investigated in seven healthy male subjects during prolonged coadministration of two drugs. Subjects were maintained on an isoenergetic, purine-free formula diet with RNA supplementation for 24 days. Allopurinol (300 mg) was given orally on days 1-24. Hydrochlorothiazide (50 mg daily) was added to days 11-21. On day 43 a single oral dose of 50 mg hydrochlorothiazide was administered. Plasma concentration-time profiles of allopurinol and its main metabolite oxipurinol were obtained on days 1, 10, and 21; hydrochlorothiazide profiles were assessed on days 21 and 43. In addition, 24-h plasma concentrations of oxipurinol were measured repetitively, and 24 h urine samples were collected for the determination of allopurinol, oxipurinol, and hydrochlorothiazide. For oxipurinol, mean Cmax was not altered on hydrochlorothiazide treatment (13.8 +/- 1.4 micrograms/ml and 14.7 +/- 2.6 micrograms/ml, respectively); mean AUC0-24 was 259 and 290 micrograms h-1 ml-1, respectively. The small difference in AUC0-24 values does not explain the increase in plasma uric acid concentration during hydrochlorothiazide treatment, nor do the variations in allopurinol and hydrochlorothiazide kinetics. |
| تدمد: | 1432-1440 0941-0198 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f60f6f6272ac23bd3e70f28484824a https://doi.org/10.1007/bf00577759 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....91f60f6f6272ac23bd3e70f28484824a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321440 09410198 |
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