Patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities
| العنوان: | Patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities |
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| المؤلفون: | Willem J. G. Melchers, Ruud L.M. Bekkers, R P de Bie, J.A. de Hullu, Albert G. Siebers, Johan Bulten, Leon F A G Massuger, H.P. van de Nieuwenhof |
| المصدر: | British Journal of Cancer, 101, 27-31 British Journal of Cancer, 101, 1, pp. 27-31 British Journal of Cancer |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Cancer Research, medicine.medical_specialty, usual vulvar intraepithelial neoplasia, Vulvar Squamous Cell Carcinoma, Uterine Cervical Neoplasms, Aetiology, screening and detection [ONCOL 5], Alphapapillomavirus, Quality of Care [ONCOL 4], Translational research [ONCOL 3], Clinical Studies, medicine, Carcinoma, Humans, Risk factor, human papillomavirus, Vulvar Diseases, Aged, Gynecology, Aged, 80 and over, Vaginal Smears, Vulvar Neoplasms, Hereditary cancer and cancer-related syndromes [ONCOL 1], integumentary system, business.industry, urogenital system, vulvar squamous cell carcinoma, Papillomavirus Infections, Cancer, cervical high-grade squamous intraepithelial lesion, Vulvar cancer, Middle Aged, Vulvar intraepithelial neoplasia, medicine.disease, Uterine Cervical Dysplasia, Dermatology, female genital diseases and pregnancy complications, Pathogenesis and modulation of inflammation [N4i 1], Squamous intraepithelial lesion, Human Reproduction [NCEBP 12], stomatognathic diseases, Oncology, Carcinoma, Squamous Cell, Female, business, Precancerous Conditions, Infection and autoimmunity [NCMLS 1], Carcinoma in Situ |
| الوصف: | Contains fulltext : 81890.pdf (Publisher’s version ) (Closed access) BACKGROUND: Vulvar squamous cell carcinoma (SCC) originates the following two pathways, related to differentiated (d) vulvar intraepithelial neoplasia (VIN) or to human papillomavirus (HPV)-related usual (u) VIN. Multicentric HPV infections (cervix, vagina and vulva) are common. We hypothesise that patients with a uVIN-related vulvar SCC more often have cervical high-grade squamous intraepithelial lesions (HSILs) compared with women with dVIN-related vulvar SCC. METHODS: All vulvar SCCs (201) were classified to be dVIN- (n=164) or uVIN related (n=37). Data with regard to the smear history and cervical histology were retrieved from PALGA, the nationwide Netherlands database of histo- and cytopathology. For HSIL cervical smears of which histology was taken, HPV DNA analysis on both the vulvar and cervical specimens was performed. RESULTS: At least one smear was available in 145 (72%) of the 201 patients. Patients with a uVIN-related vulvar SCC more often had an HSIL compared with patients with a dVIN-related SCC (35 vs 2%, P |
| وصف الملف: | application/pdf |
| تدمد: | 0007-0920 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9207706c94deea3502bc768f5bcee2c0 http://hdl.handle.net/2066/81890 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9207706c94deea3502bc768f5bcee2c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00070920 |
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