أعرض في EDS

PET/MRI-guided GTV delineation during radiotherapy planning in patients with squamous cell carcinoma of the tongue

التفاصيل البيبلوغرافية
العنوان: PET/MRI-guided GTV delineation during radiotherapy planning in patients with squamous cell carcinoma of the tongue
المؤلفون: Natalia Samołyk-Kogaczewska, Justyna Burzyńska-Śliwowska, Konrad Zuzda, Kamil Szczecina, Patryk Gugnacki, Marek Z. Wojtukiewicz, Piotr Szumowski, Małgorzata Mojsak, Ewa Sierko, Dorota Jurgilewicz
المصدر: Strahlentherapie Und Onkologie
بيانات النشر: Springer Science and Business Media LLC, 2019.
سنة النشر: 2019
مصطلحات موضوعية: Male, Biopsy, medicine.medical_treatment, Multimodal Imaging, Strahlentherapie, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Lingual carcinoma, Head and neck cancer, medicine.diagnostic_test, Makroskopisches Tumorvolumen, Middle Aged, Magnetic Resonance Imaging, Primary tumor, Tongue Neoplasms, Tumor Burden, Radiation therapy, medicine.anatomical_structure, Oncology, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Female, Original Article, medicine.drug, Adult, 03 medical and health sciences, Tongue, Kopf- und Halskarzinom, Fluorodeoxyglucose F18, Zungenkarzinom, medicine, Carcinoma, Humans, Radiology, Nuclear Medicine and imaging, In patient, Aged, Neoplasm Staging, Retrospective Studies, Fluorodeoxyglucose, business.industry, Radiotherapy Planning, Computer-Assisted, Gross tumor volume, Magnetic resonance imaging, medicine.disease, PET/MRT, PET/MRI, Positron-Emission Tomography, Tomography, X-Ray Computed, Nuclear medicine, business, Radiotherapy, Image-Guided
الوصف: Purpose The aim of the study was to evaluate the usefulness and accuracy of 18-fluorine-labeled fluorodeoxyglucose (PET) and magnetic resonance imaging (MRI) hybrid in gross tumor volume (GTV) delineation during radiotherapy planning in patients with carcinoma of the tongue. Methods Ten patients with squamous cell carcinoma (SCC) of the tongue underwent computed tomography (CT) and PET/MRI examination. The GTV for primary tumor and lymph nodes (nGTV) were defined on CT (GTV-CT) and compared to GTVs obtained from PET (GTV-PET) and MRI (GTV-MRI) images. Two methods of GTV determination were used: visual interpretation of CT, PET (GTV-PETvis) and MRI images and quantitative automatic method (Syngovia, Siemens) based on a chosen threshold value (20%, 30%, 40%, 50%) of standardized uptake values (SUVmax) from PET examination (GTV-PET20%, GTV-PET30%, etc.). Statistical analysis of differences in GTV values obtained from CT, PET and MRI studies was performed. GTV-CT was used as a reference. Results In all, 80% of GTV-MRI and 40% of GTV-PETvis were larger than GTV-CT. Respectively, 20% of GTV-MRI and 60% of GTV-PETvis were smaller than GTV-CT. Taking into account all threshold measurements, 70% of volumes were smaller than GTV-CT. GTV-PET30% were the most closely related volumes to GTV-CT from all threshold methods in 50% of patients. GTV-PETvis generated the most similar volumes in relation to GTV-CT from all PET measurements. Statistical analysis confirmed those results. Compared to nGTV-CT, 70% of nGTV-MRI and 20% of nGTV-PETvis were larger. The remaining nGTV-MRI and nGTV-PETvis measurements were smaller than nGTV-CT. Measurements of all thresholds nGTVs were smaller than nGTV-CTV in 52.5% of cases. nGTV-PET20% were the most closely related volumes to nGTV-CT in 40% of the cases. Statistical analysis showed that nGTV-PET20% (p = 0.0468), nGTV-PETvis (p = 0.0166), and nGTV-PET50% (p = 0.0166) diverge significantly from nGTV-CT results. nGTV-MRI (p = 0.1141), nGTV-PET30% (p = 0.2845), and nGTV-PET40% (p = 0.5076) were significantly related with nGTV-CT. Conclusion Combination of PET/MRI provides more information during target tumor mass delineation in radiotherapy planning of patients with SCC of the tongue than other standard imaging methods. The most frequently matching threshold value was 30% of SUVmax for primary tumor delineation and 30–40% of SUVmax for nGTV determination. Electronic supplementary material The online version of this article (10.1007/s00066-019-01480-3) contains supplementary material, which is available to authorized users.
تدمد: 1439-099X
0179-7158
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921724ba742dc656c678bc629bc87b2b
https://doi.org/10.1007/s00066-019-01480-3
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....921724ba742dc656c678bc629bc87b2b
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1439099X
01797158