Association of Enterovirus D68 with Acute Flaccid Myelitis, Philadelphia, Pennsylvania, USA, 2009–2018
| العنوان: | Association of Enterovirus D68 with Acute Flaccid Myelitis, Philadelphia, Pennsylvania, USA, 2009–2018 |
|---|---|
| المؤلفون: | Darcy Curtis, Chunyu Zhao, Jeffrey Fink, Priyanka Uprety, Ramakrishnan Rajagopalan, Erin H. Graf, Kyle Bittinger, Erlinda R. Ulloa, Michael Elkan, Stephanie L. Mitchell, Sarah Hopkins |
| المصدر: | Emerging Infectious Diseases, Vol 25, Iss 9, Pp 1676-1682 (2019) Emerging Infectious Diseases |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Pediatrics, Epidemiology, Expedited, Prevalence, lcsh:Medicine, Disease, medicine.disease_cause, Disease Outbreaks, 0302 clinical medicine, EV-D68, Paralysis, Longitudinal Studies, 030212 general & internal medicine, Child, Clade, Enterovirus D, Human, Philadelphia, enterovirus, Neuromuscular Diseases, Myelitis, Infectious Diseases, whole-genome sequencing, acute flaccid myelitis, Female, medicine.symptom, Microbiology (medical), medicine.medical_specialty, 030231 tropical medicine, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, children, Enterovirus Infections, medicine, Humans, viruses, lcsh:RC109-216, Retrospective Studies, business.industry, Research, lcsh:R, Outbreak, enterovirus D68, Pennsylvania, United States, Acute flaccid myelitis, Central Nervous System Viral Diseases, Enterovirus, Association of Enterovirus D68 with Acute Flaccid Myelitis, Philadelphia, Pennsylvania, USA, 2009–201, business, Enterovirus D68 |
| الوصف: | Acute flaccid myelitis (AFM) is a polio-like disease that results in paralysis in previously healthy persons. Although the definitive cause of AFM remains unconfirmed, enterovirus D68 (EV-D68) is suspected based on 2014 data demonstrating an increase in AFM cases concomitant with an EV-D68 outbreak. We examined the prevalence in children and the molecular evolution of EV-D68 for 2009–2018 in Philadelphia, Pennsylvania, USA. We detected widespread EV-D68 circulation in 2009, rare detections in 2010 and 2011, and then biennial circulation, only in even years, during 2012–2018. Prevalence of EV-D68 significantly correlated with AFM cases during this period. Finally, whole-genome sequencing revealed early detection of the B1 clade in 2009 and continued evolution of the B3 clade from 2016 to 2018. These data reinforce the need to improve surveillance programs for nonpolio enterovirus to identify possible AFM triggers and predict disease prevalence to better prepare for future outbreaks. |
| تدمد: | 1080-6059 1080-6040 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ab4cbf17a27dc22f3923d8f0adacc4 https://doi.org/10.3201/eid2509.190468 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....92ab4cbf17a27dc22f3923d8f0adacc4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
|---|