Near-Infrared-Triggered Photodynamic, Photothermal, and on Demand Chemotherapy by Multifunctional Upconversion Nanocomposite
| العنوان: | Near-Infrared-Triggered Photodynamic, Photothermal, and on Demand Chemotherapy by Multifunctional Upconversion Nanocomposite |
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| المؤلفون: | Supratim Giri, Irshad Mattan, Aparna Murali, Balmiki Kumar |
| المصدر: | The Journal of Physical Chemistry B. 123:3738-3755 |
| بيانات النشر: | American Chemical Society (ACS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Materials science, Infrared Rays, Surface Properties, medicine.medical_treatment, Nanoparticle, Photodynamic therapy, 010402 general chemistry, Photochemistry, 01 natural sciences, Nanocomposites, 0103 physical sciences, Organometallic Compounds, Materials Chemistry, medicine, Humans, Particle Size, Physical and Theoretical Chemistry, Surface plasmon resonance, Cell Proliferation, Antibiotics, Antineoplastic, Nanocomposite, 010304 chemical physics, technology, industry, and agriculture, Phototherapy, Photothermal therapy, Mesoporous silica, Silicon Dioxide, Photon upconversion, 0104 chemical sciences, Surfaces, Coatings and Films, Drug Liberation, Photochemotherapy, Doxorubicin, Nanorod, Gold, Drug Screening Assays, Antitumor, Reactive Oxygen Species, Porosity, HeLa Cells |
| الوصف: | In an attempt to integrate photodynamic therapy (PDT) with photothermal therapy and chemotherapy for enhanced anticancer activity, we have rationally synthesized a multifunctional upconversion nanoplatform using NaYF4:Yb/Tm/Er/Fe nanoparticles (NPs) as the core and NaYbF4:1% Tm as a shell. The as-synthesized core-shell upconversion (CSU) NPs exhibited diverse and enhanced photoluminescence emissions in a wide range (UV to NIR) consequent upon Fe3+ doping in the core and fabrication of an active shell. Subsequently, CSU was first decorated with titania NPs as photosensitizers. Next, the mesoporous silica (MS) shell loaded with doxorubicin (DOX) via a photocleavable Ru complex as the gating molecule was developed around titania-containing CSU. Finally, gold nanorods (GNRs) with localized surface plasmon resonance (LSPR) at 800 nm were incorporated around the MS layer to obtain the multifunctional nanoplatform. We demonstrated that the UV, blue, and NIR emissions from the CSU produced ROS-mediated PDT through titania activation, induced DOX release through photocleavage of the Ru complex, and generated hyperthermia by LSPR activity of GNRs, respectively, upon a single NIR excitation through FRET. The therapeutic efficacy was validated on HeLa cell lines in vitro by various microscopic and biochemical studies under a significantly milder NIR irradiation and lower dosage of the nanoplatforms, which have been further demonstrated as diagnostic nanoprobes for cell imaging. |
| تدمد: | 1520-5207 1520-6106 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92beaa193c350b367edf65f1fda56c24 https://doi.org/10.1021/acs.jpcb.9b01870 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....92beaa193c350b367edf65f1fda56c24 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205207 15206106 |
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