The role of transferrin-receptor variation in the host range of Trypanosoma brucei
| العنوان: | The role of transferrin-receptor variation in the host range of Trypanosoma brucei |
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| المؤلفون: | Herlinde Gerrits, Wilbert Bitter, Rudo Kieft, Piet Borst |
| المصدر: | Nature. 391:499-502 |
| بيانات النشر: | Springer Science and Business Media LLC, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Genes, Protozoan, Trypanosoma brucei brucei, Transferrin receptor, Trypanosoma brucei, Host-Parasite Interactions, Mice, Dogs, Receptors, Transferrin, parasitic diseases, Antigenic variation, Animals, Humans, Receptor, Gene, Genetics, chemistry.chemical_classification, Multidisciplinary, biology, fungi, Transferrin, Genetic Variation, Kinetoplastida, biology.organism_classification, chemistry, Cattle, Glycoprotein, Variant Surface Glycoproteins, Trypanosoma |
| الوصف: | Trypanosoma brucei is a unicellular parasite transmitted between African mammals by tsetse flies. T. brucei multiplies freely in the bloodstream of many different mammals, and survives by antigenic variation of the main component of its surface coat, variant surface glycoprotein (VSG). Trypanosomes take up transferrin through a heterodimeric transferrin receptor, the genes for which are expressed in telomeric expression sites along with the VSG gene. There are up to 20 of these expression sites per trypanosome nucleus, but usually only one is active at a time. Different expression sites encode transferrin receptors that are similar but not identical. Here we show that these small differences between transferrin receptors can have profound effects on the binding affinity for transferrins from different mammals, and on the ability of trypanosomes to grow in the sera of these mammals. Our results suggest that the ability to switch between different transferrin-receptor genes allows T. brucei to cope with the large sequence diversity in the transferrins of its hosts. |
| تدمد: | 1476-4687 0028-0836 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e0901053fb110f8c4ff0cf8c45bf7c https://doi.org/10.1038/35166 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....92e0901053fb110f8c4ff0cf8c45bf7c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764687 00280836 |
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