Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: implications for human type 1 diabetes
| العنوان: | Thiazolidinediones for the prevention of diabetes in the non-obese diabetic (NOD) mouse: implications for human type 1 diabetes |
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| المؤلفون: | P. E. Beales, Paolo Pozzilli |
| المصدر: | Diabetes/Metabolism Research and Reviews. 18:114-117 |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, Latent autoimmune diabetes of adults, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Rosiglitazone, Mice, Troglitazone, Endocrinology, Insulin resistance, Mice, Inbred NOD, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Animals, Hypoglycemic Agents, Chromans, NOD mice, Type 1 diabetes, business.industry, Incidence, medicine.disease, Disease Models, Animal, Thiazoles, Diabetes Mellitus, Type 1, Female, Thiazolidinediones, business, medicine.drug |
| الوصف: | Background Thiazolidinediones (TZDs) are a recently introduced generation of drugs acting as receptor agonists to reduce insulin resistance and used currently in combination with other hypoglycaemic agents for the treatment of type 2 diabetes. In addition, TZDs possess anti-inflammatory properties that make them of interest for reducing the T-cell inflammation occurring in the islets in type 1 diabetes. Methods The action of TZD treatment on diabetes incidence in the non-obese diabetic (NOD) mouse was studied by investigating the effect of rosiglitazone (RGL) (400 mg/kg body weight by gavage) from 3 weeks of age (soon after weaning) onwards and comparing its effect to that of troglitazone (TGL) given by the same route. Results We found that RGL and TGL both significantly reduced diabetes incidence by >50% in the NOD mouse compared to litter-matched control NOD mice (p |
| تدمد: | 1520-7560 1520-7552 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ef9ec85a26a710ac89b1a15baba89d https://doi.org/10.1002/dmrr.262 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....92ef9ec85a26a710ac89b1a15baba89d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15207560 15207552 |
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