Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma
| العنوان: | Isolated Adrenocorticotropic Hormone Deficiency and Severe Hypercalcemia After Destructive Thyroiditis in a Patient on Nivolumab Therapy With a Malignant Melanoma |
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| المؤلفون: | Rika Naruse, Hiroyuki Shinozaki, Tatsuhiko Suzuki, Sho Furukawa, Kenji Hara, Takafumi Tsuchiya, Kohzo Takebayashi, Atsushi Ujiie, Toshihiko Inukai, Mototaka Yamauchi, Mio Kubo |
| المصدر: | Journal of Clinical Medicine Research |
| بيانات النشر: | Elmer Press, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, Isolated ACTH deficiency, 030209 endocrinology & metabolism, Case Report, Adrenocorticotropic hormone, Gastroenterology, Thyroiditis, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Destructive thyroiditis, medicine, business.industry, Melanoma, Clinical course, General Medicine, medicine.disease, Nivolumab, 030220 oncology & carcinogenesis, Hypercalcemia, Adrenocorticotropic hormone deficiency, business, hormones, hormone substitutes, and hormone antagonists |
| الوصف: | We describe a 58-year-old man with a malignant melanoma metastasis to the liver. After initiation of nivolumab therapy, he developed destructive thyroiditis and subsequently simultaneous isolated adrenocorticotropic hormone (ACTH) deficiency and severe hypercalcemia. Although isolated ACTH deficiency and hypercalcemia due to nivolumab therapy are both rare occurrences, these conditions can often cause a severe clinical course accompanied by a disturbance of consciousness. Therefore, clinicians should pay attention to these possible side effects of nivolumab if the patients have clinical symptoms, such as fatigue and a disturbance of consciousness. |
| اللغة: | English |
| تدمد: | 1918-3011 1918-3003 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930f431bfca225e010fd647d60e5eea6 http://europepmc.org/articles/PMC5827922 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....930f431bfca225e010fd647d60e5eea6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19183011 19183003 |
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