Cerebral Blood Volume Calculated by Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging: Preliminary Correlation Study with Glioblastoma Genetic Profiles
| العنوان: | Cerebral Blood Volume Calculated by Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging: Preliminary Correlation Study with Glioblastoma Genetic Profiles |
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| المؤلفون: | Seung Chai Jung, Seung Hong Choi, Chul-Ho Sohn, A. Leum Lee, Sung Hye Park, Chul-Kee Park, Jeong A. Yeom, Tae Jin Yun, Inseon Ryoo, Hwaseon Shin, Ji Hoon Kim, Soo Chin Kim |
| المصدر: | PLoS ONE PLoS ONE, Vol 8, Iss 8, p e71704 (2013) PLOS ONE(8): 8 |
| بيانات النشر: | Public Library of Science, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Pathology, lcsh:Medicine, Contrast Media, Blood volume, Diagnostic Radiology, Tensin, Cluster Analysis, Epidermal growth factor receptor, lcsh:Science, Promoter Regions, Genetic, Neurological Tumors, Multidisciplinary, Blood Volume, biology, medicine.diagnostic_test, Brain Neoplasms, Middle Aged, Magnetic Resonance Imaging, ErbB Receptors, Perfusion, Oncology, Cerebrovascular Circulation, Immunohistochemistry, Medicine, Regression Analysis, Female, Radiology, Research Article, medicine.medical_specialty, Neuroimaging, O(6)-Methylguanine-DNA Methyltransferase, Diagnostic Medicine, medicine, Cancer Detection and Diagnosis, PTEN, Humans, Biology, Clinical Genetics, Receiver operating characteristic, lcsh:R, PTEN Phosphohydrolase, Cancers and Neoplasms, Magnetic resonance imaging, DNA Methylation, biology.protein, lcsh:Q, Tumor Suppressor Protein p53, Glioblastoma, Glioblastoma Multiforme, Neuroscience |
| الوصف: | Purpose: To evaluate the usefulness of dynamic susceptibility contrast (DSC) enhanced perfusion MR imaging in predicting major genetic alterations in glioblastomas. Materials and Methods: Twenty-five patients (M:F = 13:12, mean age: 52.1 +/- 15.2 years) with pathologically proven glioblastoma who underwent DSC MR imaging before surgery were included. On DSC MR imaging, the normalized relative tumor blood volume (nTBV) of the enhancing solid portion of each tumor was calculated by using dedicated software (Nordic TumorEX, NordicNeuroLab, Bergen, Norway) that enabled semi-automatic segmentation for each tumor. Five major glioblastoma genetic alterations (epidermal growth factor receptor (EGFR), phosphatase and tensin homologue (PTEN), Ki-67, O6-methylguanine-DNA methyltransferase (MGMT) and p53) were confirmed by immunohistochemistry and analyzed for correlation with the nTBV of each tumor. Statistical analysis was performed using the unpaired Student t test, ROC (receiver operating characteristic) curve analysis and Pearson correlation analysis. Results: The nTBVs of the MGMT methylation-negative group (mean 9.5 +/- 7.5) were significantly higher than those of the MGMT methylation-positive group (mean 5.4 +/- 1.8) (p = .046). In the analysis of EGFR expression-positive group, the nTBVs of the subgroup with loss of PTEN gene expression (mean: 10.3 +/- 8.1) were also significantly higher than those of the subgroup without loss of PTEN gene expression (mean: 5.6 +/- 2.3) (p = .046). Ki-67 labeling index indicated significant positive correlation with the nTBV of the tumor (p = .01). Conclusion: We found that glioblastomas with aggressive genetic alterations tended to have a high nTBV in the present study. Thus, we believe that DSC-enhanced perfusion MR imaging could be helpful in predicting genetic alterations that are crucial in predicting the prognosis of and selecting tailored treatment for glioblastoma patients. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9317e0edf84ae8b729e3693e58c0622d http://europepmc.org/articles/PMC3747204 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9317e0edf84ae8b729e3693e58c0622d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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