Additional file 3. Correlation of total serum Immunoglobulin compared to time since diagnosis amongst untreated patients. Legend: Correlation of serum immunoglobulin levels in untreated patients compared to time since diagnosis is shown; Spearman���s rank correlation: IgA (r = -0.019; p = 0.759) IgG (r = -0.07; p = 0.23) IgM (r = -0.15; p = 0.01).