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Autologous adipose-derived regenerative cell therapy modulates development of hypertrophic scarring in a red Duroc porcine model

التفاصيل البيبلوغرافية
العنوان: Autologous adipose-derived regenerative cell therapy modulates development of hypertrophic scarring in a red Duroc porcine model
المؤلفون: Mayer Tenenhaus, Rohit Rajoria, Diana Zafra, John K. Fraser, Philippe Foubert, Damian Gutierrez, Mike Liu
المصدر: Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-11 (2017)
بيانات النشر: Springer Science and Business Media LLC, 2017.
سنة النشر: 2017
مصطلحات موضوعية: 0301 basic medicine, Pathology, Cell Transplantation, Swine, Surgical Wound, Cell- and Tissue-Based Therapy, Gene Expression, Medicine (miscellaneous), Adipose tissue, Skin Pigmentation, Fat pad, 0302 clinical medicine, Adipose-derived regenerative cells, Adipocytes, Medicine, lcsh:QD415-436, Skin, lcsh:R5-920, Neovascularization, Pathologic, Adipose-Derived Regenerative Cells, medicine.anatomical_structure, Adipose Tissue, Molecular Medicine, Female, Collagen, medicine.symptom, Stem cell, lcsh:Medicine (General), Blood vessel, Hypertrophic scarring, medicine.medical_specialty, Cicatrix, Hypertrophic, Transplantation, Autologous, Biochemistry, Genetics and Molecular Biology (miscellaneous), lcsh:Biochemistry, 03 medical and health sciences, Hardness, Animals, Humans, Inflammation, Wound Healing, Interleukin-6, business.industry, Research, 030208 emergency & critical care medicine, Cell Biology, Hypervascularity, Hyperpigmentation, Elasticity, 030104 developmental biology, business, Wound healing
الوصف: Background Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence of deep-partial thickness injury, remain a significant clinical challenge. Previous studies from our group have shown that autologous adipose-derived regenerative cells (ADRCs) represent a promising approach to improve wound healing and, thereby, impact HTS development. The purpose of this study was to assess the influence of local delivery of ADRCs immediately following deep-partial thickness cutaneous injury on HTS development in the red Duroc (RD) porcine model. Methods Bilateral pairs of deep-partial thickness excisional wounds (2 mm depth; 58 cm2 area) were created using an electric dermatome on RD pigs (n = 12). Autologous ADRCs were isolated from the inguinal fat pad and then sprayed directly onto the wound at a dose of 0.25 × 106 viable cells/cm2. The paired contralateral wound received vehicle control. Wound healing and development of HTS were assessed over 6 months using digital imaging, quantitative measurement of skin hardness and pigmentation, and histology. Results Data showed that ADRC treatment led to reduced scar hyperpigmentation compared to control (p
تدمد: 1757-6512
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934f5127f40e50960022a765f907e6e5
https://doi.org/10.1186/s13287-017-0704-1
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....934f5127f40e50960022a765f907e6e5
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17576512