Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones
| العنوان: | Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones |
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| المؤلفون: | Shisong Fang, Chenyang Li, Tie Chen, Yongai Xiong, Jun Song, Haiqiang Wu, Zhendan He, Weihua Wu, Chi Sing Lee, Xin Wang, Mengxun Zhang |
| المصدر: | Organic & Biomolecular Chemistry. 19:2481-2486 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Organic Chemistry, Substrate (chemistry), Epoxy, Electrolyte, Electrochemistry, Biochemistry, Peroxide, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Transition metal, visual_art, Yield (chemistry), visual_art.visual_art_medium, Physical and Theoretical Chemistry, Redox mediator |
| الوصف: | A novel electrochemical method for the synthesis of α,β-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones in gram-scales for evaluation of their anti-cancer activities. |
| تدمد: | 1477-0539 1477-0520 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9357a174ae0f27c66831b0e6d23bbbcd https://doi.org/10.1039/d0ob02444a |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....9357a174ae0f27c66831b0e6d23bbbcd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770539 14770520 |
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