Clinical Manifestations of Nipah Virus–Infected Patients Who Presented to the Emergency Department During an Outbreak in Kerala State in India, May 2018
| العنوان: | Clinical Manifestations of Nipah Virus–Infected Patients Who Presented to the Emergency Department During an Outbreak in Kerala State in India, May 2018 |
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| المؤلفون: | M K Sreejith, Attayur P. Sugunan, Radhakrishnan Chandni, Manoj V Murhekar, K P Suraj, Arshad Fazal, A Remla Beevi, R L Sarita, Devendra T. Mourya, Govindakarnavar Arunkumar, K. G. Sajeeth Kumar, N K Thulaseedharan, Noufel Yoosef, Ashhar C, V.R. Rajendran, T P Renjith |
| المصدر: | Clinical Infectious Diseases. 71:152-157 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Microbiology (medical), Pediatrics, medicine.medical_specialty, Myocarditis, Barrier nursing, 030231 tropical medicine, India, Physical examination, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Case fatality rate, Humans, Medicine, 030212 general & internal medicine, Henipavirus Infections, medicine.diagnostic_test, business.industry, Nipah Virus, Outbreak, Emergency department, medicine.disease, Infectious Diseases, Etiology, Female, Emergency Service, Hospital, business, Encephalitis |
| الوصف: | Background An outbreak of Nipah virus (NiV) disease occurred in the Kozhikode district of Kerala State in India in May 2018. Several cases were treated at the emergency medicine department (ED) of the Government Medical College, Kozhikode (GMCK). The clinical manifestations and outcome of these cases are described. Methods The study included 12 cases treated in the ED of GMCK. Detailed clinical examination, laboratory investigations, and molecular testing for etiological diagnosis were performed. Results The median age of the patients was 30 years and the male to female ratio was 1.4:1.0. All the cases except the index case contracted the infection from hospitals. The median incubation period was 10 days, and the case fatality ratio was 83.3%. Ten (83.3%) patients had encephalitis and 9 out of 11 patients whose chest X-rays were obtained had bilateral infiltrates. Three patients had bradycardia and intractable hypotension requiring inotropes. Encephalitis, acute respiratory distress syndrome, and myocarditis were the clinical prototypes, but there were large overlaps between these. Ribavirin therapy was given to a subset of the patients. Although there was a 20% reduction in NiV encephalitis cases treated with the drug, the difference was not statistically significant. The outbreak ended soon after the introduction of total isolation of patients and barrier nursing. Conclusion The outbreak of NiV disease in Kozhikode in May 2018 presented as encephalitis, acute respiratory distress and myocarditis or combinations of these. The CFR was high. Ribavirin therapy was tried but no evidence for its benefit could be obtained. |
| تدمد: | 1537-6591 1058-4838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9373f291d089e11e99844371f5f1d65d https://doi.org/10.1093/cid/ciz789 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9373f291d089e11e99844371f5f1d65d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
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