Nonimmune Hydrops Fetalis in the Liveborn: Series of 32 Autopsies
| العنوان: | Nonimmune Hydrops Fetalis in the Liveborn: Series of 32 Autopsies |
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| المؤلفون: | Maria M. Rodriguez, Eduardo Bancalari, Otto L. Garcia, Jocelyn H. Bruce, Peter L. Ferrer, Rita L. Romaguera, Xavier F. Jiménez |
| المصدر: | Pediatric and Developmental Pathology. 8:369-378 |
| بيانات النشر: | SAGE Publications, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Heart Defects, Congenital, Male, medicine.medical_specialty, Myocarditis, Heart disease, Hydrops Fetalis, 030204 cardiovascular system & hematology, Pathology and Forensic Medicine, Pulmonary sequestration, 03 medical and health sciences, 0302 clinical medicine, Male Urogenital Diseases, Pregnancy, Internal medicine, Hydrops fetalis, medicine, Humans, Congenital nephrotic syndrome, business.industry, Infant, Newborn, Pregnancy Outcome, Endocardial fibroelastosis, General Medicine, medicine.disease, Female Urogenital Diseases, Cardiovascular Diseases, 030220 oncology & carcinogenesis, Heart failure, Pediatrics, Perinatology and Child Health, Cardiology, Noonan syndrome, Female, Autopsy, business |
| الوصف: | Nonimmune hydrops fetalis (NIHF) or generalized soft tissue edema and cavity effusions may be due to cardiovascular diseases, congenital infections, genitourinary malformations, thoracic masses, placental conditions, chromosomal abnormalities, and idiopathic. We report 32 cases of NIHF from among 429 neonates who underwent autopsies (incidence 7.45%). Sixteen cases (50%) had cardiovascular disease; all were due to low output cardiac failure; 7 had structural congenital heart disease. Three of the children with congenital heart disease also had chromosomal abnormalities: 2 had trisomy 18 and 1 had Noonan syndrome. Among myocardial conditions were five subjects with cardiomyopathies (1 of each of the following types): oncocytic, dilated, endocardial fibroelastosis, cardiac glycogenosis, and carnitine deficiency; 3 had myocarditis, and 1 had cardiac rhabdomyomas. Congenital infections were due to cytomegalovirus in 3 cases, bacteria in 2, and parvovirus in 1. The mechanism of NIHF in these cases might be a combination of decreased myocardial contractility due to myocarditis and fetal anemia. Genitourinary diseases were present in 5 newborns: Two had congenital nephrotic syndrome, 1 had VACTER association, 1 had prune-belly syndrome, and 1 had urogenital sinus malformation. Intrathoracic lesions were found in 2 babies (pulmonary sequestration and diaphragmatic hernia). One twin died of volume overload due to twin transfusion syndrome. Only 2 newborns were classified as idiopathic. Our study shows that cardiovascular diseases that lead to heart failure or impaired venous return are more common in the liveborn (50%), whereas congenital infections are more common in the stillborn with NIHF. |
| تدمد: | 1615-5742 1093-5266 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937dace740570b05b9490b99977a4615 https://doi.org/10.1007/s10024-005-8089-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....937dace740570b05b9490b99977a4615 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16155742 10935266 |
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