Host Determinants of Reinfection with Schistosomes in Humans: A Systematic Review and Meta-analysis
العنوان: | Host Determinants of Reinfection with Schistosomes in Humans: A Systematic Review and Meta-analysis |
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المؤلفون: | Anita Carolle Akpeedje Wadagni, Nguyen Tien Huy, Kenji Hirayama, Obioma C. Nwaorgu, CI Eneanya, Evaristus Chibunna Mbanefo |
المصدر: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3164 (2014) |
بيانات النشر: | Public Library of Science (PLoS), 2014. |
سنة النشر: | 2014 |
مصطلحات موضوعية: | Epidemiology, Psychological intervention, Plant Science, Disease, Global Health, Disease Informatics, Recurrence, Zoonoses, Medicine and Health Sciences, Schistosomiasis, Public and Occupational Health, lcsh:Public aspects of medicine, Infectious Diseases, Veterinary Diseases, Helminth Infections, Meta-analysis, Schistosoma, Disease Susceptibility, Research Article, Neglected Tropical Diseases, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, Infectious Disease Control, lcsh:RC955-962, Disease Surveillance, Microbiology, Infectious Disease Epidemiology, Host-Parasite Interactions, Parasitic Diseases, medicine, Animals, Humans, business.industry, Public health, Public Health, Environmental and Occupational Health, Biology and Life Sciences, lcsh:RA1-1270, Publication bias, Odds ratio, Plant Pathology, Tropical Diseases, medicine.disease, Social Epidemiology, Biomarker Epidemiology, Immunology, Parasitology, Veterinary Science, business, Demography |
الوصف: | Background: Schistosomiasis is still a major public health burden in the tropics and subtropics. Although there is an effective chemotherapy (Praziquantel) for this disease, reinfection occurs rapidly after mass drug administration (MDA). Because the entire population do not get reinfected at the same rate, it is possible that host factors may play a dominant role in determining resistance or susceptibility to reinfection with schistosomes. Here, we systematically reviewed and meta-analyzed studies that reported associations between reinfection with the principal human-infecting species (S. mansoni, S. japonicum and S. haematobium) and host socio-demographic, epidemiological, immunological and genetic factors. Methodology/Principal Findings: PubMed, Scopus, Google Scholar, Cochrane Review Library and African Journals Online public databases were searched in October 2013 to retrieve studies assessing association of host factors with reinfection with schistosomes. Meta-analysis was performed to generate pooled odds ratios and standardized mean differences as overall effect estimates for dichotomous and continuous variables, respectively. Quality assessment of included studies, heterogeneity between studies and publication bias were also assessed. Out of the initial 2739 records, 109 studies were included in the analyses, of which only 32 studies with 37 data sets were eligible for quantitative data synthesis. Among several host factors identified, strong positive association was found with age and pre-treatment intensity, and only slightly for gender. These factors are major determinants of exposure and disease transmission. Significant positive association was found with anti-SWA IgG4 level, and a negative overall effect for association with IgE levels. This reconfirmed the concept that IgE/IgG4 balance is a major determinant of protective immunity against schistosomiasis. Other identified determinants were reported by a small number of studies to enable interpretation. Conclusions: Our data contribute to the understanding of host-parasite interaction as it affects reinfection, and is a potential tool to guide planning and tailoring of community interventions to target high-risk groups. PLoS Neglected Tropical Diseases, 8(9), e3164; 2014 |
وصف الملف: | application/pdf |
تدمد: | 1935-2735 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a092fda93e3df775900cbfe0b42239 https://doi.org/10.1371/journal.pntd.0003164 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....93a092fda93e3df775900cbfe0b42239 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 19352735 |
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