Detecting Recurrence Following Lobectomy for Thyroid Cancer: Role of Thyroglobulin and Thyroglobulin Antibodies
| العنوان: | Detecting Recurrence Following Lobectomy for Thyroid Cancer: Role of Thyroglobulin and Thyroglobulin Antibodies |
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| المؤلفون: | Aviram Mizrachi, Talia Diker-Cohen, Amit Ritter, Gideon Bachar, Hadar Duskin-Bitan, Igor Vainer, Ilan Shimon, Dania Hirsch, Eyal Robenshtok |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 105:e2145-e2151 |
| بيانات النشر: | The Endocrine Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Urology, 030209 endocrinology & metabolism, Thyroid Lobectomy, Thyroglobulin, Biochemistry, Thyroiditis, Papillary thyroid cancer, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Biomarkers, Tumor, medicine, Humans, Thyroid Neoplasms, Child, Lymph node, Thyroid cancer, Aged, Autoantibodies, Retrospective Studies, Aged, 80 and over, Completion thyroidectomy, business.industry, Biochemistry (medical), Middle Aged, Prognosis, medicine.disease, Carcinoma, Papillary, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Thyroidectomy, Female, Lymph, Neoplasm Recurrence, Local, business, Follow-Up Studies |
| الوصف: | Background The use of thyroglobulin (Tg) and thyroglobulin antibodies (TgAb) for detecting disease recurrence is well validated following total thyroidectomy and radioiodine ablation. However, limited data are available for patients treated with thyroid lobectomy. Methods Patients who had lobectomy for papillary thyroid cancer followed for >1 year, with sufficient data on Tg and TgAb, including subgroup analysis for Hashimoto’s thyroiditis and contralateral nodules. Results One-hundred sixty-seven patients met the inclusion criteria. Average tumor size was 9.5 ± 6 mm. Following lobectomy, Tg was 12.1 ± 14.8 ng/mL. Of 52 patients with Hashimoto’s thyroiditis, 38% had positive TgAb with titers of 438 ± 528 IU/mL, and in patients without TgAb the mean Tg level was 14.7 ± 19.0 ng/mL. In 34 patients with contralateral nodules ≥1 cm, Tg was 15.3 ± 17 ng/mL. During the first 2 years of follow-up, Tg declined ≥1 ng/mL in 42% of patients (by 5.1 ± 3.7 ng/mL), remained stable in 22%, and increased in 36% (by 4.9 ± 5.7 ng/mL). During a mean follow-up of 6.5 years (78 ± 43.5 months), 18 patients had completion thyroidectomy and 12 were diagnosed with contralateral cancer (n = 8) or lymph node metastases (n = 4). In patients with recurrence followed for >2 years, there was a rise in Tg in 3 cases, Tg was stable in 2 cases, and in 1 TgAb decreased from 1534 to 276 IU/mL despite metastatic lymph nodes. Basal Tg and Tg dynamics did not predict disease recurrence. Conclusions Serum thyroglobulin used independently is of limited value for predicting or detecting disease recurrence following thyroid lobectomy. Other potential roles of Tg, such as detecting distant metastases following lobectomy, should be further studied. |
| تدمد: | 1945-7197 0021-972X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ae489549e54ce67c22237ab459d3d8 https://doi.org/10.1210/clinem/dgaa152 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....93ae489549e54ce67c22237ab459d3d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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