أعرض في EDS

Ligase-Controlled Cyclo-oligomerization of Peptides

التفاصيل البيبلوغرافية
العنوان: Ligase-Controlled Cyclo-oligomerization of Peptides
المؤلفون: Xinya Hemu, James P. Tam, Xiaohong Zhang
المساهمون: School of Biological Sciences
المصدر: Organic Letters. 21:2029-2032
بيانات النشر: American Chemical Society (ACS), 2019.
سنة النشر: 2019
مصطلحات موضوعية: chemistry.chemical_classification, DNA ligase, Bacteria, Molecular Structure, 010405 organic chemistry, Stereochemistry, Chemistry, Organic Chemistry, Peptides And Proteins, Biological sciences [Science], Peptide, 010402 general chemistry, Peptides, Cyclic, 01 natural sciences, Biochemistry, Catalysis, 0104 chemical sciences, Amino acid, Ligases, Residue (chemistry), Depsipeptides, Molecule, Amino Acids, Physical and Theoretical Chemistry
الوصف: A biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-, length-, and sequence-dependent. This reaction yields cyclic mono-, di-, tri-, and tetramers from peptide precursors containing 3-15 amino acids ended with Asn and a His-Val tail. The cyclomonomers were favored when the peptide lengths were >9 amino acids. A turn-forming Pro residue at the P2 position favored the formation of higher-order cyclo-oligomers. Ministry of Education (MOE) Accepted version We thank National University Hospital of Singapore for providing the drug-resistant bacteria strains for the research purpose. This research was supported by Academic Research Grant Tier 3 (MOE2016-T3-1-003) from Singapore Minister of Education (MOE).
وصف الملف: application/pdf
تدمد: 1523-7052
1523-7060
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c086bbd44da7e1b863d85e8175ad99
https://doi.org/10.1021/acs.orglett.9b00151
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....93c086bbd44da7e1b863d85e8175ad99
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15237052
15237060