التفاصيل البيبلوغرافية
العنوان:
Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study
المؤلفون:
Matthew K Hensley , Jana L. Jacobs , Bernard J.C. Macatangay , Rahil Sethi , Ashwin Somasundaram , Feng Shan , Ghady Haidar , Brittany Staines , Anthony R. Cillo , Janet S. Lee , Linda J. Rennick , Amy Heaps , Anuradha Ray , Michele D. Sobolewski , William Bain , Barbara Methé , Tullia C. Bruno , Prabir Ray , Dario A. A. Vignali , John W. Mellors , William E. Schwarzmann , Georgios D Kitsios , W. Paul Duprex , Urvi M. Parikh , Creg J. Workman , Carly Cardello , Cynthia Klamar-Blain , Mounzer Agha , Sham Nambulli , Kevin D. McCormick , Mark S. Ladinsky , Pamela J. Bjorkman , Alison Morris
المصدر:
Clinical Infectious Diseases
بيانات النشر:
Oxford University Press, 2021.
سنة النشر:
2021
مصطلحات موضوعية:
0301 basic medicine , Microbiology (medical) , T cell , viruses , Cell- and Tissue-Based Therapy , Virus Replication , medicine.disease_cause , 03 medical and health sciences , 0302 clinical medicine , Antigen , Immunity , medicine , Humans , 030212 general & internal medicine , Coronavirus , Receptors, Chimeric Antigen , SARS-CoV-2 , Transmission (medicine) , business.industry , Brief Report , SARS-CoV-2 infectivity , SARS-CoV-2 intrahost variation , COVID-19 , Virology , Chimeric antigen receptor , SARS-CoV-2 RNAemia , AcademicSubjects/MED00290 , 030104 developmental biology , medicine.anatomical_structure , Infectious Diseases , Viral replication , Viral evolution , SARS-CoV-2 immune responses , business , severe acute respiratory syndrome coronavirus 2
الوصف:
A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 1010 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.
وصف الملف:
application/pdf; application/msword
اللغة:
English
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f1eae762c64dfc3bf3ebdefe98e881 https://resolver.caltech.edu/CaltechAUTHORS:20210201-145608486
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....93f1eae762c64dfc3bf3ebdefe98e881
قاعدة البيانات:
OpenAIRE
