Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study
| العنوان: | Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study |
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| المؤلفون: | Hao Li, Changyuan Wang, Yue Jin, Yuanqing Cai, Jialin Yao, Qiang Meng, Jingjing Wu, Huihan Wang, Huijun Sun, Mozhen Liu |
| المصدر: | Phytotherapy research : PTRREFERENCES. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology |
| الوصف: | Isopsoralen (IPRN), which comes from the fruit of Psoralea corylifolia, has been identified as a kind of phytoestrogen and has been proven to be effective for the treatment of osteoporosis (OP). However, the mechanisms underlying IPRN's anti-OP effects, especially the anti-postmenopausal osteoporosis (PMOP) effects, remain indistinct. Thus, this study aimed to investigate the effects and mechanisms of IPRN's anti-PMOP activity. In this study, the bioinformatics results predicted that IPRN could resist PMOP by targeting EGFR, AKT1, SRC, CCND1, ESR1 (ER-α), AR, PGR, BRCA1, PTGS2, and IGF1R. An ovariectomized (OVX) mice model and a H |
| تدمد: | 1099-1573 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9418a6461e7a3236130d51d01b96444c https://pubmed.ncbi.nlm.nih.gov/36123318 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....9418a6461e7a3236130d51d01b96444c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991573 |
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