التفاصيل البيبلوغرافية
| العنوان: |
BALB/c mice display more enhanced BCG vaccine induced Th1 and Th17 response than C57BL/6 mice but have equivalent protection |
| المؤلفون: |
Véronique S. Bachy, Philip J. Hogarth, M. Carmen Garcia-Pelayo, Daryan A. Kaveh |
| المصدر: |
Tuberculosis. 95:48-53 |
| بيانات النشر: |
Elsevier BV, 2015. |
| سنة النشر: |
2015 |
| مصطلحات موضوعية: |
Microbiology (medical), C57BL/6, medicine.medical_treatment, Immunology, Spleen, Tuberculosis, Splenic, Microbiology, BALB/c, Th1, Immune system, Adjuvants, Immunologic, Bacterial Proteins, Immunity, medicine, Tuberculosis, Animals, BCG, Tuberculosis, Pulmonary, Antigens, Bacterial, Immunity, Cellular, Mice, Inbred BALB C, Mycobacterium bovis, biology, Th1 Cells, biology.organism_classification, Recombinant Proteins, Mice, Inbred C57BL, Infectious Diseases, medicine.anatomical_structure, Cytokine, BCG Vaccine, Cytokines, Th17 Cells, Female, Th17, Vaccine, BCG vaccine |
| الوصف: |
summary It is generally assumed that the inbred mouse strains BALB/c (H-2 d ) and C57BL/6 (H-2 b ) respond to mycobacterial infection with distinct polarisation of T helper responses, with C57BL/6 predisposed toTh1 and BALB/c to Th2. We investigated this in a BCG-immunisation, Mycobacterium bovis challenge model. Following immunisation, lung and spleen cell cytokine responses to in vitro re-stimulation with a cocktail of seven secreted, immunogenic, recombinant mycobacterial proteins were determined. In both lung and spleen, BALB/c cells produced at least 2-fold more IFN-g, and up to 7-fold more IL-2 and IL-17 than C57BL/6 cells, whereas IL-10 production was reciprocally increased in C57BL/6 mice. These data suggest that, contrary to reports in the literature, specific mycobacterial antigens are able to induce strong Th1 and Th17 responses in BALB/c mice following BCG vaccination, whilst in C57BL/6 mice, the Th1 response is partly counterbalanced by IL-10. After subsequent M. bovis low dose challenge, protection, as measured in the lungs and dissemination to the spleen, was equivalent in BALB/c and C57BL/6 mice, indicating that BCG-induced immunity was equivalent in both strains. Thus, the differential immune responses do not appear to have a role in protection, but further, as yet unidentified, specific immune responses play a significant role. Crown Copyright © 2014 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
| تدمد: |
1472-9792 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942633e15d37c3df763fad9ad9483bf5
https://doi.org/10.1016/j.tube.2014.10.012 |
| حقوق: |
OPEN |
| رقم الأكسشن: |
edsair.doi.dedup.....942633e15d37c3df763fad9ad9483bf5 |
| قاعدة البيانات: |
OpenAIRE |
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