Expression of Heme Oxygenase-1 Protects Endothelial Cells from Irradiation-Induced Apoptosis
| العنوان: | Expression of Heme Oxygenase-1 Protects Endothelial Cells from Irradiation-Induced Apoptosis |
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| المؤلفون: | Reinhard Andreesen, Günther Eissner, Andrea Wilke, Armin Gerbitz, Patricia Ewing, Ernst Holler |
| المصدر: | Endothelium. 12:113-119 |
| بيانات النشر: | Informa UK Limited, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Metalloporphyrins, Physiology, Cell, Apoptosis, Cell Line, Mice, chemistry.chemical_compound, medicine, Animals, Heme, Radiotherapy, biology, X-Rays, Cytochrome c, Cytochromes c, Endothelial Cells, Cell Biology, General Medicine, COPP, Cell biology, Enzyme Activation, Heme oxygenase, Endothelial stem cell, medicine.anatomical_structure, chemistry, Cell culture, biology.protein, Heme Oxygenase-1 |
| الوصف: | A common side effect of therapeutic use of ionizing irradiation is endothelial cell damage resulting in a variety of clinical complications. Thus, preservation of endothelial function after irradiation could potentially limit toxicity. Using the murine endothelioma cell line bEnd2 we show here that induction of heme oxygenase-1 (HO-1) by cobalt protoporphyrine IX (CoPP) inhibits irradiation-induced apoptosis. In contrast, HO-1 induction by tin protoporphyrine IX (SnPP), a HO-1 inhibitor, does not affect survival after irradiation. The protective effects of CoPP could be partially reversed by blockade of HO-1 function with SnPP after induction by CoPP. Vice versa, blockade of HO-1 function by SnPP was reversible using CoPP. Treatment with CoPP inhibited cytochrome c release induced by irradiation. These results demonstrate that HO-1 induction and activation prior to irradiation inhibits endothelial apoptosis and might be used for possible cell protection in vivo. |
| تدمد: | 1029-2373 1062-3329 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949275fa7c18b2edd02bba750c551844 https://doi.org/10.1080/10623320500189814 |
| رقم الأكسشن: | edsair.doi.dedup.....949275fa7c18b2edd02bba750c551844 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 10292373 10623329 |
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