Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling
| العنوان: | Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling |
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| المؤلفون: | Ester Pernjak-Pugel, Martina Pavletić Peršić, Marko Škoda, Robert Domitrović, Iva Potočnjak |
| المصدر: | Molecular nutrition & food research Volume 60 Issue 3 |
| بيانات النشر: | Wiley, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_treatment, Administration, Oral, BIOMEDICINA I ZDRAVSTVO. Farmacija, Pharmacology, Kidney, medicine.disease_cause, chemistry.chemical_compound, Oral administration, BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Medical Biochemistry, Medicine, Iridoids, Enzyme Inhibitors, Blood urea nitrogen, Mice, Inbred BALB C, Nephritis, apoptosis, Acute kidney injury, cisplatin nephrotoxicity, Acute Kidney Injury, medicine.anatomical_structure, inflammation, MAPK, oleuropein, Biotechnology, MAP Kinase Signaling System, Iridoid Glucosides, Intraperitoneal injection, BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Medicinska biokemija, Antineoplastic Agents, Protective Agents, 03 medical and health sciences, Oleuropein, Animals, Creatinine, business.industry, medicine.disease, BIOMEDICINE AND HEALTHCARE. Pharmacy, Oxidative Stress, 030104 developmental biology, chemistry, Immunology, Cisplatin, business, Oxidative stress, Food Science |
| الوصف: | Oleuropein possesses numerous health beneficial effects. We investigated the renoprotective effects of oleuropein against cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally gavaged with 5, 10 and 20 mg oleuropein/kg body weight for two days, 48 h after intraperitoneal injection of CP (13 mg/kg). Four days after CP administration, serum creatinine and blood urea nitrogen (BUN) levels were significantly elevated, with histopathological changes in renal tissue. In addition, renal oxidative stress was evidenced by increased expression of 3-nitrotyrosine (3-NT), 4-hydroxynonenal (4-HNE), cytochrome P450 E1 (CYP2E1) and heme oxygenase-1 (HO-1). The expression of nuclear factor-kappaB (NF-κB) p65, phospho-p65, tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2) in the kidneys increased upon CP treatment, suggesting renal inflammation. CP intoxication increased the expression of p53, Bax and caspase-3 and induced apoptosis in the kidneys. CP administration also resulted in enhanced phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2). All these effects were dose-dependently diminished by oleuropein. Oral administration of PD0325901, an MEK inhibitor, coincided with the oleuropein-mediated suppression of apoptotic, inflammatory and antioxidant markers. The results of the current study suggest that oleuropein attenuated CP-induced acute renal injury, which was mediated through the inhibition of ERK signaling. |
| وصف الملف: | application/pdf |
| تدمد: | 1613-4125 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94bb6c1e9690f1121d6d4f4beb79adb8 https://doi.org/10.1002/mnfr.201500409 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....94bb6c1e9690f1121d6d4f4beb79adb8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16134125 |
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