Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice
| العنوان: | Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice |
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| المؤلفون: | Nicholas R. Hum, Crystal Jaing, Deepa K. Murugesh, James B. Thissen, Melanie E. Mendez, Gabriela G. Loots, Michael A. Malfatti, Edward A. Kuhn |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific reports, vol 10, iss 1 |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Metabolite, Antibiotics, lcsh:Medicine, Administration, Oral, Gut flora, Pharmacology, Urine, Inbred C57BL, 030226 pharmacology & pharmacy, chemistry.chemical_compound, Mice, 0302 clinical medicine, Ampicillin, Drug Interactions, Tissue Distribution, lcsh:Science, Multidisciplinary, biology, digestive, oral, and skin physiology, Neomycin, Anti-Bacterial Agents, 5.1 Pharmaceuticals, Administration, Development of treatments and therapeutic interventions, medicine.drug, Oral, medicine.drug_class, Cmax, digestive system, Article, Vaccine Related, 03 medical and health sciences, Pharmacokinetics, medicine, Animals, Metabolomics, Acetaminophen, lcsh:R, Amoxicillin, biology.organism_classification, Gastrointestinal Microbiome, Mice, Inbred C57BL, 030104 developmental biology, chemistry, lcsh:Q, Microbiome |
| الوصف: | The gut microbiota is a vast and diverse microbial community that has co-evolved with its host to perform a variety of essential functions involved in the utilization of nutrients and the processing of xenobiotics. Shifts in the composition of gut microbiota can disturb the balance of organisms which can influence the biodisposition of orally administered drugs. To determine how changes in the gut microbiome can alter drug disposition, the pharmacokinetics (PK), and biodistribution of acetaminophen were assessed in C57Bl/6 mice after treatment with the antibiotics ciprofloxacin, amoxicillin, or a cocktail of ampicillin/neomycin. Altered PK, and excretion profiles of acetaminophen were observed in antibiotic exposed animals. Plasma Cmax was significantly decreased in antibiotic treated animals suggesting decreased bioavailability. Urinary metabolite profiles revealed decreases in acetaminophen-sulfate metabolite levels in both the amoxicillin and ampicillin/neomycin treated animals. The ratio between urinary and fecal excretion was also altered in antibiotic treated animals. Analysis of gut microbe composition revealed that changes in microbe content in antibiotic treated animals was associated with changes in acetaminophen biodisposition. These results suggest that exposure to amoxicillin or ampicillin/neomycin can alter the biodisposition of acetaminophen and that these alterations could be due to changes in gut microbiome composition. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f72f3303348d2c697c6cf2498570bb http://europepmc.org/articles/PMC7067795 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....94f72f3303348d2c697c6cf2498570bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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