Association of Self-Rated Health With Functional Limitations in Patients With CKD
| العنوان: | Association of Self-Rated Health With Functional Limitations in Patients With CKD |
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| المؤلفون: | Manisha Jhamb, Manqi Cai, Jonathan G. Yabes, Hsin-Hsiung Chang, Jacqueline Lee, Khaled Abdel-Kader |
| المصدر: | Kidney Medicine |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Activities of daily living, Logistic regression, functional status, self-rated health, instrumental activities of daily living, Quality of life, Internal Medicine, limitations in activities of daily living, Medicine, Outpatient clinic, Prospective cohort study, cognitive function, Self-rated health, Original Research, business.industry, Confounding, executive function, quality of life, Nephrology, Cohort, Physical therapy, Ambulation, business, human activities, chronic kidney disease |
| الوصف: | Rationale & Objective In patients with chronic kidney disease (CKD), self-rated health (“In general, how do you rate your health?”) is associated with mortality. The association of self-rated health with functional status is unknown. We evaluated the association of limitations in activities of daily living (ADLs) with self-rated health and clinical correlates in a cohort of patients with CKD stages 1-5. Study Design Prospective cohort study. Setting & Participants Patients with CKD at a nephrology outpatient clinic in western Pennsylvania. Outcome Patients participated in a survey assessing their self-rated health (5-point Likert scale) and physical (ambulation, dressing, shopping) and cognitive (executive and memory) ADLs. Adjusted analysis was performed using logistic regression models. Analytical Approach Logistic regression was conducted to examine the adjusted association of 3 dependent variables (sum of total, physical, and cognitive ADL limitations) with self-rated health (independent variable of interest). Results The survey was completed by 1,268 participants (mean age, 60 years; 49% females, and 74% CKD stages 3-5), of which 41% reported poor-to-fair health. Overall, 35.9% had at least 1 physical ADL limitation, 22.1% had at least 1 cognitive ADL limitation, and 12.5% had at least 3 ADL limitations. Ambulation was the most frequently reported limitation and was more common in patients reporting poor-to-fair self-rated health compared with those with good-to-excellent self-rated health (58.1% vs 17.4%, P < 0.001). In our fully adjusted model, poor-to-fair self-rated health was strongly associated with limitations in at least 3 ADLs (total ADL) [OR 8.29 (95% CI, 5.23-13.12)]. There was no significant association of eGFR with ADL limitations. Limitations Selection bias due to optional survey completion, residual confounding, and use of abbreviated (as opposed to full) ADL questionnaires. Conclusions Poor-to-fair self-rated health is strongly associated with physical ADL limitations in patients with CKD. Future studies should evaluate whether self-rated health questions may be useful for identifying patients who can benefit from additional evaluation and treatment of functional limitations to improve patient-centered outcomes. Graphical abstract |
| اللغة: | English |
| تدمد: | 2590-0595 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955202f82d422afd00c184f869ccb9f4 http://europepmc.org/articles/PMC8515078 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....955202f82d422afd00c184f869ccb9f4 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 25900595 |
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