Neonatal leptin antagonism improves metabolic programming of postnatally overnourished mice
| العنوان: | Neonatal leptin antagonism improves metabolic programming of postnatally overnourished mice |
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| المؤلفون: | Gustav Colldén, Emilie Caron, Sebastien G. Bouret |
| المساهمون: | Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) |
| المصدر: | International Journal of Obesity International Journal of Obesity, 2022, 46 (6), pp.1138-1144. ⟨10.1038/s41366-022-01093-4⟩ |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Leptin, Mice, Overnutrition, Nutrition and Dietetics, Pregnancy, Endocrinology, Diabetes and Metabolism, Hypothalamus, Animals, Medicine (miscellaneous), Female, Obesity, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Weight Gain |
| الوصف: | International audience; Background/Objectives: Alteration of the perinatal nutritional environment is an important risk factor for the development of metabolic diseases in later life. The hormone leptin plays a critical role in growth and development. Previous studies reported that postnatal overnutrition increases leptin secretion during the pre-weaning period. However, a direct link between leptin, neonatal overnutrition, and lifelong metabolic regulation has not been investigated.Methods: We used the small litter mouse model combined with neonatal leptin antagonist injections to examine whether attenuating leptin during early life improves lifelong metabolic regulation in postnatally overnourished mice.Results: Postnatally overnourished mice displayed rapid weight gain during lactation and remained overweight as adults. These mice also showed increased adiposity and perturbations in glucose homeostasis in adulthood. Neonatal administration of a leptin antagonist normalized fat mass and insulin sensitivity in postnatally overnourished mice. These metabolic improvements were associated with enhanced sensitivity of hypothalamic neurons to leptin.Conclusions: Early postnatal overnutrition causes metabolic alterations that can be permanently attenuated with the administration of a leptin antagonist during a restricted developmental window. |
| تدمد: | 1476-5497 0307-0565 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9571f62f2780431e951a80b66e7b9310 https://doi.org/10.1038/s41366-022-01093-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....9571f62f2780431e951a80b66e7b9310 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765497 03070565 |
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