Immunosuppression as a Hallmark of Critical COVID-19: Prospective Study
| العنوان: | Immunosuppression as a Hallmark of Critical COVID-19: Prospective Study |
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| المؤلفون: | Tomasz Wróbel, Danuta Nowicka-Suszko, Justyna Rybka, Aleksander Zińczuk, Adrian Martuszewski, Monika Biernat, Barbara Adamik, Krzysztof Simon, Elżbieta Kalicińska, Waldemar Gozdzik, Tomasz Skalec, Aleksandra Bogucka-Fedorczuk, Jakub Smiechowicz, Donata Szymczak |
| المصدر: | Cells Volume 10 Issue 6 Cells, Vol 10, Iss 1293, p 1293 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, QH301-705.5, T cell, medicine.medical_treatment, Critical Illness, T cells, NK cells, CD16, Adaptive Immunity, Risk Assessment, Severity of Illness Index, Article, regulatory T cells, Immune tolerance, Leukocyte Count, IL-2/INFγ ratio, medicine, Immune Tolerance, TNFα, Humans, Hospital Mortality, Prospective Studies, Biology (General), Prospective cohort study, Aged, immunosuppression, lymphocyte subsets, Clinical Deterioration, business.industry, SARS-CoV-2, IL-2, COVID-19, Immunosuppression, General Medicine, Middle Aged, TCRα/β, Acquired immune system, Immunity, Innate, INFγ, Hospitalization, medicine.anatomical_structure, Peripheral blood lymphocyte, Immunology, Tumor necrosis factor alpha, Female, Poland, TCR γ/δ cells, business |
| الوصف: | The dysregulation of both the innate and adaptive responses to SARS-CoV-2 have an impact on the course of COVID-19, and play a role in the clinical outcome of the disease. Here, we performed a comprehensive analysis of peripheral blood lymphocyte subpopulations in 82 patients with COVID-19, including 31 patients with a critical course of the disease. In COVID-19 patients who required hospitalization we analyzed T cell subsets, including Treg cells, as well as TCRα/β and γ/δ, NK cells, and B cells, during the first two weeks after admission to hospital due to the SARS-CoV-2 infection, with marked reductions in leukocytes subpopulations, especially in critically ill COVID-19 patients. We showed decreased levels of Th, Ts cells, Treg cells (both naïve and induced), TCRα/β and γ/δ cells, as well as CD16+CD56+NK cells in ICU compared to non-ICU COVID-19 patients. We observed impaired function of T and NK cells in critically ill COVID-19 patients with extremely low levels of secreted cytokines. We found that the IL-2/INFγ ratio was the strongest indicator of a critical course of COVID-19, and was associated with fatal outcomes. Our findings showed markedly impaired innate and adaptive responses in critically ill COVID-19 patients, and suggest that the immunosuppressive state in the case of a critical course of SARS-CoV-2 infection might reflect subsequent clinical deterioration and predict a fatal outcome. |
| وصف الملف: | application/pdf |
| تدمد: | 2073-4409 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95aaf65e5e7f86de4b782125a01e4877 https://pubmed.ncbi.nlm.nih.gov/34071149 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....95aaf65e5e7f86de4b782125a01e4877 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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