Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry with High Myopia
| العنوان: | Prevalence of Myopic Macular Features in Dutch Individuals of European Ancestry with High Myopia |
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| المؤلفون: | Haarman, A.E.G., Tedja, M.S., Brussee, C., Enthoven, C.A., Rijn, G.A. van, Vingerling, J.R., Keunen, J.E.E., Boon, C.J.F., Geerards, A.J.M., Luyten, G.P.M., Verhoeven, V.J.M., Klaver, C.C.W. |
| المساهمون: | Ophthalmology, ANS - Complex Trait Genetics, Epidemiology, Clinical Psychology, Clinical Genetics |
| المصدر: | JAMA Ophthalmology Jama Ophthalmology, 140, 115-123 Jama Ophthalmology, 140, 2, pp. 115-123 JAMA ophthalmology. American Medical Association JAMA Ophthalmology, 140(2), 115-123. American Medical Association JAMA Ophthalmology, 140(2), 115-123. AMER MEDICAL ASSOC |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, genetic structures, Research, Visual Acuity, Middle Aged, Global Health, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], Choroidal Neovascularization, eye diseases, Featured, Cohort Studies, Ophthalmology, Macular Degeneration, Cross-Sectional Studies, Retinal Diseases, Myopia, Degenerative, Prevalence, Myopia, Online First, Humans, Female, sense organs, Comments, Original Investigation |
| الوصف: | This cross-sectional study assesses the frequency of myopic macular features in individuals of European ancestry with high myopia. Key Points Question What is the prevalence of myopic macular degeneration in Dutch individuals of European ancestry with high myopia? Findings In this cross-sectional study of 626 individuals with European ancestry with high myopia, the prevalence of myopic macular degeneration was 25.9% and increased with older age, lower spherical equivalent of refractive error, and higher axial length. Meaning Myopic retinal features were frequent in this highly myopic study population, but not different than patients of Asian ancestry with similar risk profiles. Importance High myopia incidence and prevalence is increasing worldwide, and the visual burden caused by myopia is expected to rise accordingly. Studies investigating the occurrence of myopic complications in individuals of European ancestry with high myopia are scarce, hampering insights into the frequency of myopic retinal complications in European individuals and their visual burden. Objective To assess the frequency of myopic macular features in individuals of European ancestry with high myopia. Design, Setting, and Participants This cross-sectional analysis of the Dutch Myopia Study (MYST) and individuals with high myopia from the Rotterdam Study (RS) included 626 patients with high myopia (spherical equivalent of refractive error [SER] ≤−6 diopters [D] or axial length [AL] ≥26 mm) who underwent an extensive ophthalmic examination including multimodal retinal imaging. In addition to this combination of a population-based cohort study and mix-based high myopia study, a systematic literature review was also performed to compare findings with studies of individuals of Asian ancestry. Exposures High myopia, age, and AL. Main Outcomes and Measures Frequency of myopic macular and optic disc features: tessellated fundus, myopic macular degeneration (MMD), staphyloma, peripapillary intrachoroidal cavitation, peripapillary atrophy (PPA), and “plus” lesions (choroidal neovascularization, Fuchs spot, and lacquer cracks). Results The mean (SD) SER of the combined study population (MYST and RS) was −9.9 (3.2) D; the mean (SD) age was 51.4 (15.1) years, and 387 (61.8%) were women. The prevalence of MMD was 25.9% and increased with older age (P for trend |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2168-6165 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95aedaa18c2e4149e6e577433d6762ce http://www.scopus.com/inward/record.url?scp=85121561346&partnerID=8YFLogxK |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....95aedaa18c2e4149e6e577433d6762ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21686165 |
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