Efficacy of L-carnitine supplementation for improving lean body mass and physical function in patients on hemodialysis: a randomized controlled trial
| العنوان: | Efficacy of L-carnitine supplementation for improving lean body mass and physical function in patients on hemodialysis: a randomized controlled trial |
|---|---|
| المؤلفون: | Terumi Higuchi, Maki Kitai, Masanori Abe, Chinami Nagura, Takashi Maruyama, Kei Utsunomiya, Tetsuya Furukawa, Fumito Kikuchi, Hideyuki Ando, Toshio Yamazaki, Ritsukou Tei, Noriaki Maruyama, Hiroyuki Takashima, Erina Okawa |
| المصدر: | European Journal of Clinical Nutrition. 73:293-301 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Urology, Medicine (miscellaneous), 030209 endocrinology & metabolism, Protein-Energy Malnutrition, law.invention, Young Adult, 03 medical and health sciences, Grip strength, 0302 clinical medicine, Japan, Muscular Diseases, Randomized controlled trial, Renal Dialysis, law, Carnitine, Activities of Daily Living, medicine, Humans, Hyperammonemia, Prospective Studies, Prospective cohort study, Dialysis, Aged, Aged, 80 and over, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Middle Aged, Treatment Outcome, Dietary Supplements, Body Composition, Lean body mass, Kidney Failure, Chronic, Female, Hemodialysis, Cardiomyopathies, business, Body mass index, medicine.drug |
| الوصف: | Carnitine deficiency is common in patients on hemodialysis. However, the efficacy of L-carnitine supplementation for improving lean body mass (LBM) and physical function has not yet been evaluated. In this multicenter, prospective, parallel, randomized, controlled trial, 91 patients on hemodialysis who developed carnitine deficiency were randomly assigned to receive injections of 1,000 mg L-carnitine 3 times per week after each hemodialysis session (L-carnitine group) or no injections (control group) with monitoring for 12 months. The data for 84 of the 91 patients were available for analysis (L-carnitine group, n = 42; control group, n = 42). Dry weight and body mass index did not significantly change in the l-carnitine group, but significantly decreased in the control group. Arm muscle area (AMA) did not change significantly in the L-carnitine group but decreased significantly in the control group; the difference in mean AMA between the groups was 6.22% (95% confidence interval [CI] 1.90–10.5; P = 0.037). Hand grip strength did not change significantly in the L-carnitine group, but decreased significantly in the control group. The difference in change in hand grip strength between the groups was 4.27% (95% CI 0.42–8.12; P = 0.030). Furthermore, LBM did not change significantly in the l-carnitine group but decreased significantly in the control group; the difference in mean LBM between the groups was 2.92 % (95% CI 1.28–4.61; P = 0.0007). l-carnitine supplementation is useful in patients who develop carnitine deficiency on hemodialysis because it maintains physical function and LBM. |
| تدمد: | 1476-5640 0954-3007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9615af8bf681875db76bb9ffdc5f5d88 https://doi.org/10.1038/s41430-018-0348-y |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....9615af8bf681875db76bb9ffdc5f5d88 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14765640 09543007 |
|---|