Tissue factor in ulcerative colitis, with and without concomitant primary sclerosing cholangitis
| العنوان: | Tissue factor in ulcerative colitis, with and without concomitant primary sclerosing cholangitis |
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| المؤلفون: | Mikael Åberg, Johan Vessby, Agneta Siegbahn, Fredrik Rorsman, Alkwin Wanders, Marie Carlson, Maria Lampinen |
| المصدر: | Upsala Journal of Medical Sciences Upsala Journal of Medical Sciences, Vol 124, Iss 4, Pp 238-245 (2019) |
| بيانات النشر: | Taylor & Francis, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, endocrine system diseases, Biopsy, IBD, Cholangitis, Sclerosing, lcsh:Medicine, Severe disease, Gastroenterology and Hepatology, Gastroenterology, digestive system, Primary sclerosing cholangitis, Thromboplastin, Tissue factor, Young Adult, Internal medicine, medicine, Gastroenterologi, Humans, In patient, Intestinal Mucosa, ulcerative colitis, Aged, Inflammation, business.industry, Incidence (epidemiology), lcsh:R, digestive, oral, and skin physiology, primary sclerosing cholangitis, General Medicine, Articles, Middle Aged, medicine.disease, tissue factor, Flow Cytometry, Ulcerative colitis, Immunohistochemistry, digestive system diseases, PSC-UC, Concomitant, immunohistochemistry, Leukocytes, Mononuclear, Colitis, Ulcerative, Female, business, Biomarkers |
| الوصف: | Background: Ulcerative colitis (UC) in patients with the severe disease primary sclerosing cholangitis (PSC) constitutes a distinct clinical phenotype (PSC-UC) with a high incidence of colorectal cancer. Today, PSC-UC diagnosis is built on clinical observations only. Tissue factor (TF) has a potential use in UC diagnostics, and also in colorectal cancer prognostication. Here we evaluate TF expression in an inflammatory bowel disease (IBD) cohort, with special focus on differences between UC and PSC-UC patients. Materials and methods: Colonic biopsies from UC (n = 23), PSC (n = 24), and healthy controls (n = 11) were stained for TF by immunohistochemistry. Mononuclear cell contribution to TF expression was verified using flow cytometry. Results: TF was distributed at three distinct colonic locations: in subepithelial pericryptal sheath cells, in mononuclear cells, and in the intestinal stroma. In contrast to UC—where inflammation was accompanied with TF up-regulation—PSC-UC activity remained low during inflammation. Stromal TF positivity was found exclusively in ongoing inflammation. Conclusion: Our study provides additional support for a divergent pathogenesis in PSC-UC, with an inflammatory environment that differs from classical UC. Stromal TF emerges as a new marker of colonic inflammation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2000-1967 0300-9734 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963ab557186a35b5f28c275747d6d4a0 http://europepmc.org/articles/PMC6968534 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....963ab557186a35b5f28c275747d6d4a0 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 20001967 03009734 |
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