Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells
| العنوان: | Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells |
|---|---|
| المؤلفون: | Liqing Cheng, Zhanqi Wei, Zaopeng Yang, Renlin Lu, Ming Yang, Muchun Yu, Naixue Yang, Shulin Li, Mingyi Gao, Xueqiang Zhao, Xin Lin |
| المصدر: | The Journal of Immunology. 209:456-464 |
| بيانات النشر: | The American Association of Immunologists, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Mice, Liver, Immunology, Hepatocytes, NF-kappa B, Animals, Endothelial Cells, Immunology and Allergy, Mitochondria |
| الوصف: | Carma3 is an intracellular scaffolding protein that can form complex with Bcl10 and Malt1 to mediate G protein–coupled receptor– or growth factor receptor–induced NF-κB activation. However, the in vivo function of Carma3 has remained elusive. Here, by establishing a Con A–induced autoimmune hepatitis model, we show that liver injury is exacerbated in Carma3−/− mice. Surprisingly, we find that the Carma3 expression level is higher in liver sinusoidal endothelial cells (LSECs) than in hepatocytes in the liver. In Carma3−/− mice, Con A treatment induces more LSEC damage, accompanied by severer coagulation. In vitro we find that Carma3 localizes at mitochondria and Con A treatment can trigger more mitochondrial damage and cell death in Carma3-deficient LSECs. Taken together, our data uncover an unrecognized role of Carma3 in maintaining LSEC integrity, and these results may extend novel strategies to prevent liver injury from toxic insults. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963fbfac1543b88101614b83eefa8979 https://doi.org/10.4049/jimmunol.2101195 |
| رقم الأكسشن: | edsair.doi.dedup.....963fbfac1543b88101614b83eefa8979 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
|---|