Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors III. Effect of Ring Opening of Piperazinone Moiety on Inhibition
| العنوان: | Synthesis and Evaluation of 1-Arylsulfonyl-3-piperazinone Derivatives as Factor Xa Inhibitors III. Effect of Ring Opening of Piperazinone Moiety on Inhibition |
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| المؤلفون: | Fumihiko Saitoh, Hidenori Mochizuki, Atsushi Okamoto, Hidemitsu Nishida, Yoshitaka Hosaka, Hiroyasu Shimada, Tomokazu Matsusue, Yutaka Miyazaki, Takafumi Mukaihira, Kazuhiro Suzuki, Masashi Mizuno, Miwa Matsumoto, Shuhei Ohnishi |
| المصدر: | Chemical and Pharmaceutical Bulletin. 52:459-462 |
| بيانات النشر: | Pharmaceutical Society of Japan, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, medicine.drug_mechanism_of_action, Stereochemistry, Factor Xa Inhibitor, Ethylenediamine, General Chemistry, General Medicine, Ring (chemistry), Piperazines, Structure-Activity Relationship, chemistry.chemical_compound, Piperazine, chemistry, Drug Discovery, medicine, Structure–activity relationship, Moiety, Indicators and Reagents, Lower activity, Factor Xa Inhibitors |
| الوصف: | Compounds containing an ethylenediamine structure in place of the piperazine ring of M55113 (1) and M55551 (2) were synthesized to investigate the effects of a piperazine moiety and evaluated for activity as factor Xa (FXa) inhibitors. Most such compounds, however, exhibited lower activity (1/10-1/100) than that of M55113 and M55551 as FXa inhibitors. |
| تدمد: | 1347-5223 0009-2363 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96901fe22bd499b167748b2c8c5337a9 https://doi.org/10.1248/cpb.52.459 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....96901fe22bd499b167748b2c8c5337a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475223 00092363 |
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