Long-Term Efficacy of Biodegradable Metal–Polymer Composite Stents After the First and the Second Implantations into Porcine Coronary Arteries
| العنوان: | Long-Term Efficacy of Biodegradable Metal–Polymer Composite Stents After the First and the Second Implantations into Porcine Coronary Arteries |
|---|---|
| المؤلفون: | Jiandong Ding, Yongli Qi, Wanqian Zhang, Gui Zhang, Hong Qiu, Hongjie Zhang, Xun Ma, Jie Qian, Runlin Gao, Xin Li, Yao He, Deyuan Zhang, Haiping Qi, Lin Wenjiao |
| المصدر: | ACS Applied Materials & Interfaces. 12:15703-15715 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | congenital, hereditary, and neonatal diseases and abnormalities, Materials science, Swine, Iron, Polyesters, medicine.medical_treatment, 02 engineering and technology, engineering.material, Coronary Angiography, 010402 general chemistry, 01 natural sciences, Coating, Absorbable Implants, Materials Testing, Coronary stent, medicine, Animals, General Materials Science, Stent, Microcomputed tomography, equipment and supplies, 021001 nanoscience & nanotechnology, Coronary Vessels, Biodegradable polymer, 0104 chemical sciences, Corrosion, Coronary arteries, Surface coating, medicine.anatomical_structure, engineering, Polymer composites, Stents, 0210 nano-technology, Tomography, Optical Coherence, Biomedical engineering |
| الوصف: | A biodegradable coronary stent is expected to eliminate the adverse events of an otherwise eternally implanting material after vessel remodeling. Both biocorrodible metals and biodegradable polymers have been tried as the matrix of the new-generation stent. Herein, we utilized a metal-polymer composite material to combine the advantages of the high mechanical strength of metals and the adjustable degradation rate of polymers to prepare the biodegradable stent. After coating polylactide (PLA) on the surface of iron, the degradation of iron was accelerated significantly owing to the decrease of local pH resulting from the hydrolysis of PLA, etc. We implanted the metal-polymer composite stent (MPS) into the porcine artery and examined its degradation in vivo, with the corresponding metal-based stent (MBS) as a control. Microcomputed tomography (micro-CT), coronary angiography (CA), and optical coherence tomography (OCT) were performed to observe the stents and vessels during the animal experiments. The MPS exhibited faster degradation than MBS, and the inflammatory response of MPS was acceptable 12 months after implantation. Additionally, we implanted another MPS after 1-year implantation of the first MPS to investigate the result of the MPS in the second implantation. The feasibility of the biodegradable MPS in second implantation in mammals was also confirmed. |
| تدمد: | 1944-8252 1944-8244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969c3350ba7bb9965642f6451e23fa7e https://doi.org/10.1021/acsami.0c00971 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....969c3350ba7bb9965642f6451e23fa7e |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 19448252 19448244 |
|---|