Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications
| العنوان: | Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications |
|---|---|
| المؤلفون: | Xiaofang Xing, Xiaolong Wu, Ziyu Li, Xiao-Huan Tang, Jiafu Ji, Xiangyu Gao, Ting Guo |
| المصدر: | Molecular Cancer Molecular Cancer, Vol 20, Iss 1, Pp 1-15 (2021) |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Epithelial-Mesenchymal Transition, RNA, Untranslated, Review, Biology, medicine.disease_cause, Exosomes, Exosome, Helicobacter Infections, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, medicine, Biomarkers, Tumor, Tumor Microenvironment, Animals, Humans, Molecular Targeted Therapy, Neoplasm Metastasis, RC254-282, Neoplasm Staging, Progression, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, Biomarker, Non-coding RNA, medicine.disease, Prognosis, ncRNA, Microvesicles, Cell biology, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Disease Progression, Molecular Medicine, Biomarker (medicine), Tumor Escape, Disease Susceptibility, Carcinogenesis, Gastric cancer, Biogenesis |
| الوصف: | Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. Exosomes are derived from nearly all types of cells and exist in all body fluids. Noncoding RNAs (ncRNAs) are among the most abundant contents in exosomes, and some ncRNAs with biological functions are specifically packaged into exosomes. Recent studies have revealed that exosome-derived ncRNAs play crucial roles in the tumorigenesis, progression and drug resistance of gastric cancer (GC). In addition, regulating the expression levels of exosomal ncRNAs can promote or suppress GC progression. Moreover, the membrane structures of exosomes protect ncRNAs from degradation by enzymes and other chemical substances, significantly increasing the stability of exosomal ncRNAs. Specific hallmarks within exosomes that can be used for exosome identification, and specific contents can be used to determine their origin. Therefore, exosomal ncRNAs are suitable for use as diagnostic and prognostic biomarkers or therapeutic targets. Regulating the biogenesis of exosomes and the expression levels of exosomal ncRNAs may represent a new way to block or eradicate GC. In this review, we summarized the origins and characteristics of exosomes and analysed the association between exosomal ncRNAs and GC development. |
| اللغة: | English |
| تدمد: | 1476-4598 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c1c8773798947d4e9d1e0f42e2e93b http://europepmc.org/articles/PMC8323226 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....96c1c8773798947d4e9d1e0f42e2e93b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14764598 |
|---|