IL-10-Producing B Cells Are Induced Early in HIV-1 Infection and Suppress HIV-1-Specific T Cell Responses
| العنوان: | IL-10-Producing B Cells Are Induced Early in HIV-1 Infection and Suppress HIV-1-Specific T Cell Responses |
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| المؤلفون: | Connie J. Kim, Gabor Gyenes, Wei Zhan, Sonya A. MacParland, Jordan A. Schwartz, Hanqi Zhao, Erika Benko, Jun Liu, Hai Han Song, Colin Kovacs, Blake E. Ziegler, Jin Chao Cao, Alexander Gregor, Rupert Kaul, Mario A. Ostrowski, Feng Yun Yue, Kiera L. Clayton, Sanja Huibner, Erika Lee |
| المصدر: | PLoS ONE, Vol 9, Iss 2, p e89236 (2014) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | B Cells, Immune Cells, T-Lymphocytes, Regulatory B cells, T cell, Naive B cell, Retrovirology and HIV immunopathogenesis, lcsh:Medicine, HIV Infections, Viral diseases, Biology, Lymphocyte Activation, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Virology, medicine, Humans, Cytotoxic T cell, lcsh:Science, Antigen-presenting cell, B cell, Immune Evasion, 030304 developmental biology, B-Lymphocytes, Regulatory, 0303 health sciences, Multidisciplinary, CD40, T Cells, lcsh:R, HIV, HIV diagnosis and management, Viral Load, Interleukin-10, 3. Good health, B-1 cell, medicine.anatomical_structure, Immunology, HIV-1, biology.protein, Medicine, Infectious diseases, Clinical Immunology, HIV clinical manifestations, lcsh:Q, Viral Transmission and Infection, Research Article, 030215 immunology |
| الوصف: | A rare subset of IL-10-producing B cells, named regulatory B cells (Bregs), suppresses adaptive immune responses and inflammation in mice. In this study, we examined the role of IL-10-producing B cells in HIV-1 infection. Compared to uninfected controls, IL-10-producing B cell frequencies were elevated in both blood and sigmoid colon during the early and chronic phase of untreated HIV-1 infection. Ex vivo IL-10-producing B cell frequency in early HIV-1 infection directly correlated with viral load. IL-10-producing B cells from HIV-1 infected individuals were enriched in CD19(+)TIM-1(+) B cells and were enriched for specificity to trimeric HIV-1 envelope protein. Anti-retroviral therapy was associated with reduced IL-10-producing B cell frequencies. Treatment of B cells from healthy donors with microbial metabolites and Toll-like receptor (TLR) agonists could induce an IL-10 producing phenotype, suggesting that the elevated bacterial translocation characteristic of HIV-1 infection may promote IL-10-producing B cell development. Similar to regulatory B cells found in mice, IL-10-producing B cells from HIV-1-infected individuals suppressed HIV-1-specific T cell responses in vitro, and this suppression is IL-10-dependent. Also, ex vivo IL-10-producing B cell frequency inversely correlated with contemporaneous ex vivo HIV-1-specific T cell responses. Our findings show that IL-10-producing B cells are induced early in HIV-1 infection, can be HIV-1 specific, and are able to inhibit effective anti-HIV-1 T cell responses. HIV-1 may dysregulate B cells toward Bregs as an immune evasion strategy. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cfc1dfe262f3c8a7f776ded736dc61 https://doi.org/10.1371/journal.pone.0089236 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....96cfc1dfe262f3c8a7f776ded736dc61 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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