Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography
| العنوان: | Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography |
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| المؤلفون: | Jie Lin Sun, De Ke Jiang, Liqun Huang, Jianfeng Xu, Shan Cheng Ren, Jun Qi, Guo Peng Yu, Ying Hao Sun, Yi Shuo Wu, Dingwei Ye, Qiang Ding, Hai Tao Chen, Yao Zhu, Fang Liu, Rong Na, Gui Ming Zhang, Hao Wen Jiang, Siqun Zheng |
| المصدر: | Asian Journal of Andrology, Vol 18, Iss 4, Pp 633-638 (2016) Asian Journal of Andrology |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Prostate biopsy, Biopsy, Urology, 030232 urology & nephrology, urologic and male genital diseases, lcsh:RC870-923, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Predictive Value of Tests, Prostate, medicine, prostate-specific antigen, Humans, Prospective cohort study, Prostate Health Index, Aged, Digital Rectal Examination, Ultrasonography, Aged, 80 and over, Gynecology, [-2]proPSA, medicine.diagnostic_test, business.industry, prostate cancer, receiver operating curve, Prostatic Neoplasms, General Medicine, Rectal examination, Middle Aged, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, Prostate-specific antigen, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Transrectal ultrasonography, Original Article, business |
| الوصف: | The [-2]proPSA (p2PSA) and its derivatives, the p2PSA-to-free PSA ratio (%p2PSA), and the Prostate Health Index (PHI) have greatly improved discrimination between men with and without prostate cancer (PCa) in prostate biopsies. However, little is known about their performance in cases where a digital rectal examination (DRE) and transrectal ultrasonography (TRUS) are negative. A prospective cohort of 261 consecutive patients in China with negative DRE and TRUS were recruited and underwent prostate biopsies. A serum sample had collected before the biopsy was used to measure various PSA derivatives, including total prostate-specific antigen (tPSA), free PSA, and p2PSA. For each patient, the free-to-total PSA ratio (%fPSA), PSA density (PSAD), p2PSA-to-free PSA ratio (%p2PSA), and PHI were calculated. Discriminative performance was assessed using the area under the receiver operating characteristic curve (AUC) and the biopsy rate at 91% sensitivity. The AUC scores within the entire cohort with respect to age, tPSA, %fPSA, PSAD, p2PSA, %p2PSA, and PHI were 0.598, 0.751, 0.646, 0.789, 0.814, 0.808, and 0.853, respectively. PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1-20 ng ml −1 . Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, thereby avoiding unnecessary procedures. The use of PHI could improve the accuracy of PCa detection by predicting prostate biopsy outcomes among men with a negative DRE and TRUS in China. |
| اللغة: | English |
| تدمد: | 1745-7262 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e4c076c5b74d9eda4e245578b11b8c http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=4;spage=633;epage=638;aulast=Yu |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....96e4c076c5b74d9eda4e245578b11b8c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17457262 |
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