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Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs

التفاصيل البيبلوغرافية
العنوان: Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs
المؤلفون: Michael Kneissl, Tim Wernicke, Johannes Schleusener, Martin Guttmann, Martina C. Meinke, Ulrike Winterwerber, Lucas Wittenbecher, Paula Zwicker, Luca Sulmoni, Markus Weyers, Silke B. Lohan, Thomas Filler, Ulrike Woggon, Neysha Lobo-Ploch, Axel Kramer, Claudia Sicher, Johannes Glaab, Hyun Kyong Cho, Frank Mehnke, Sven Einfeldt, Heiko Gundlach, Sylvia Hagedorn
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, Disease prevention, Swine, Ultraviolet Rays, DNA damage, Disinfectant, Science, 02 engineering and technology, medicine.disease_cause, Radiation Tolerance, 01 natural sciences, Article, Microbiology, Agar plate, Postoperative Complications, Skin Physiological Phenomena, 0103 physical sciences, medicine, Animals, Porcine skin, Irradiation, Skin, 010302 applied physics, Cross Infection, Microbial Viability, Multidisciplinary, biology, Chemistry, 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik, 021001 nanoscience & nanotechnology, biology.organism_classification, Drug Resistance, Multiple, Disinfection, Clinical Practice, Staphylococcus aureus, Inorganic LEDs, Infectious diseases, Medicine, 0210 nano-technology, Biomedical engineering, Bacteria, DNA Damage
الوصف: Multiresistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) cause serious postoperative infections. A skin tolerant far-UVC (2. MRSA bacteria in different concentrations on blood agar plates were inactivated with irradiation doses in the range of 15–40 mJ/cm2. Porcine skin irradiated with a dose of 40 mJ/cm2 at 233 nm showed only 3.7% CPD and 2.3% 6-4PP DNA damage. Corresponding irradiation at 254 nm caused 11–14 times higher damage. Thus, the skin damage caused by the disinfectant doses is so small that it can be expected to be compensated by the skin's natural repair mechanisms. LED-based far-UVC lamps could therefore soon be used in everyday clinical practice to eradicate multiresistant pathogens directly on humans.
اللغة: English
تدمد: 2045-2322
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970f2e780e0a33cf5ea93e751e5c6b4c
https://doaj.org/article/b236578f9a8f4b3189007bc71395130c
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....970f2e780e0a33cf5ea93e751e5c6b4c
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20452322