Development of Chitosan-Gelatin Nanofibers with Cellulose Nanocrystals for Skin Protection Applications
| العنوان: | Development of Chitosan-Gelatin Nanofibers with Cellulose Nanocrystals for Skin Protection Applications |
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| المؤلفون: | Houcine Abidi, Diana Ferreira, Ana S. Ribeiro, Sofia M. Costa, Raúl Fangueiro |
| المساهمون: | Universidade do Minho |
| المصدر: | Key Engineering Materials. 893:45-55 |
| بيانات النشر: | Trans Tech Publications, Ltd., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | food.ingredient, Materials science, Nanofibers, 02 engineering and technology, 010402 general chemistry, Biodegradable polymers, 01 natural sciences, Gelatin, Natural extracts, Chitosan, chemistry.chemical_compound, food, General Materials Science, Skin protection, Electrospinning, Mechanical Engineering, 021001 nanoscience & nanotechnology, Cellulose nanocrystals (CNC), Biodegradable polymer, Drug delivery systems, 0104 chemical sciences, Cellulose nanocrystals, Chemical engineering, chemistry, Mechanics of Materials, Wound dressing, Nanofiber, Antibacterial activity, 0210 nano-technology |
| الوصف: | In this work, natural-based and biodegradable nanofibers were produced by electrospinning for drug delivery and wound dressing applications, using gelatin (Gel), chitosan (CS), cellulose nanocrystals (CNC) and natural propolis extract. The polymeric formulations and electrospinning parameters were optimized, resulting in the development of Gel/CS nanofibers with mean diameters of 97 nm. CNC were successfully introduced into the optimized Gel/CS solution and the viscosity and conductivity values were recorded. The developed nanofibers were characterized using FESEM, ATR-FTIR, TGA and WCA. The incorporation of different CNC concentrations improved the solutions’ electrospinnability and the membranes’ physical integrity. Defect-free and uniform Gel/CS/CNC nanofibers were observed by FESEM images, and the fibers’ diameters slight increased. The hydrophilic character was maintained after the CNC incorporation. Finally, Gel/CS/CNC/Propolis nanofibers demonstrated antibacterial activity against both Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria The authors are thankful to TSSiPRO project, operation code NORTE01-0145-FEDER-000015. The authors are also grateful to FCT, Portugal for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020) and to 2C2T (UID/CTM/00264/2019). D. P. Ferreira thank the national funding by FCT through the individual scientific employment program-contract (CEECIND/02803/2017) and S. M. Costa thank the FCT PhD Scholarship (SFRH/BD/147517/2019). |
| وصف الملف: | application/pdf |
| تدمد: | 1662-9795 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97125c256e9a815d439fd81166554d08 https://doi.org/10.4028/www.scientific.net/kem.893.45 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....97125c256e9a815d439fd81166554d08 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16629795 |
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