Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene expression analyses
| العنوان: | Early specification of CD8+ T lymphocyte fates during adaptive immunity revealed by single-cell gene expression analyses |
|---|---|
| المؤلفون: | Patrick J. Metz, John T. Chang, Boyko Kakaradov, Stephanie H. Kim, Janilyn Arsenio, Gene W. Yeo |
| المصدر: | Nature immunology |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Interleukin 2, Cellular differentiation, Lymphocyte, Immunology, T lymphocyte, Biology, Acquired immune system, Article, 3. Good health, medicine.anatomical_structure, Immune system, medicine, Immunology and Allergy, IL-2 receptor, CD8, medicine.drug |
| الوصف: | T lymphocytes responding to microbial infection give rise to effector cells that mediate acute host defense and memory cells that provide long-lived immunity, but the fundamental question of when and how these cells arise remains unresolved. Here we combined single-cell gene-expression analyses with 'machine-learning' approaches to trace the transcriptional 'roadmap' of individual CD8(+) T lymphocytes throughout the course of an immune response in vivo. Gene-expression signatures predictive of eventual fates could be discerned as early as the first T lymphocyte division and may have been influenced by asymmetric partitioning of the receptor for interleukin 2 (IL-2Rα) during mitosis. Our findings emphasize the importance of single-cell analyses in understanding fate determination and provide new insights into the specification of divergent lymphocyte fates early during an immune response to microbial infection. |
| اللغة: | English |
| تدمد: | 1529-2916 1529-2908 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971b37ab38c7e9bba17cfc0585607668 http://europepmc.org/articles/PMC3968536 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....971b37ab38c7e9bba17cfc0585607668 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292916 15292908 |
|---|