Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators
| العنوان: | Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators |
|---|---|
| المؤلفون: | Assel Ten, Tulegen Seilkhanov, Indira Sagatbekova, L. K. Baktybayeva, Darya Zolotareva, Valentina Yu, K. D. Praliyev, Alexey Zazybin |
| المصدر: | Journal of Chemistry, Vol 2018 (2018) |
| بيانات النشر: | Hindawi Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Ammonium carbonate, Article Subject, 010405 organic chemistry, Chemistry, Regeneration (biology), Strecker amino acid synthesis, General Chemistry, Decane, Granulocyte, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, lcsh:Chemistry, Haematopoiesis, chemistry.chemical_compound, medicine.anatomical_structure, lcsh:QD1-999, medicine, Organic chemistry, Bone marrow, Cyanohydrin |
| الوصف: | Spiroconnected N-alkoxyalkylpiperidine hydantoins were obtained via the Strecker reaction of cyanohydrin with ammonium carbonate. 1,3,8-Triazaspiro[4.5]decane-2,4-diones have shown the myelostimulating activity in the artificially induced (with cyclophosphamide) myelodepressive syndrome. The compounds significantly accelerated the regeneration of lymphocyte and granulocyte cell pool of bone marrow hematopoiesis. |
| وصف الملف: | text/xhtml |
| تدمد: | 2090-9071 2090-9063 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975823e0ccb472673f30b5fe2cd2b7a6 https://doi.org/10.1155/2018/7346835 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....975823e0ccb472673f30b5fe2cd2b7a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20909071 20909063 |
|---|