Type I Interferons in NeuroHIV
| العنوان: | Type I Interferons in NeuroHIV |
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| المؤلفون: | Victoria E. Thaney, Marcus Kaul |
| المصدر: | Viral Immunology. 32:7-14 |
| بيانات النشر: | Mary Ann Liebert Inc, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, AIDS Dementia Complex, Immunology, Central nervous system, Reviews, HIV Infections, Neuropathology, Virus Replication, Antiviral Agents, Neuroprotection, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Acquired immunodeficiency syndrome (AIDS), Virology, medicine, Animals, Humans, Innate immune system, business.industry, Neurodegeneration, Brain, Interferon-alpha, Interferon-beta, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Interferon Type I, Central Nervous System Viral Diseases, HIV-1, Molecular Medicine, 030211 gastroenterology & hepatology, business, Neurocognitive |
| الوصف: | Infection with Human Immunodeficiency Virus (HIV)-1 continues to cause HIV-associated neurocognitive disorders despite combined antiretroviral therapy. Interferons (IFNs) are important for any antiviral immune response, but the lasting production of IFNα causes exhaustive activation leading eventually to progression to AIDS. Expression of IFNα in the HIV-exposed central nervous system has been linked to cognitive impairment and inflammatory neuropathology. In contrast, IFNβ exerts anti-inflammatory effects, appears to control, at least temporarily, lentiviral infection in the brain and provides neuroprotection. The dichotomy of type I IFN effects on HIV-1 infection and the associated brain injury will be discussed in this review, because the underlying mechanisms require further investigation to allow harnessing these innate immune factors for therapeutic purposes. |
| تدمد: | 1557-8976 0882-8245 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977eff719923e09628ab7604e05c5e2f https://doi.org/10.1089/vim.2018.0085 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....977eff719923e09628ab7604e05c5e2f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578976 08828245 |
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