Salvage Boron Neutron Capture Therapy for Malignant Brain Tumor Patients in Compliance with Emergency and Compassionate Use: Evaluation of 34 Cases in Taiwan
| العنوان: | Salvage Boron Neutron Capture Therapy for Malignant Brain Tumor Patients in Compliance with Emergency and Compassionate Use: Evaluation of 34 Cases in Taiwan |
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| المؤلفون: | Tien Li Lan, Robert Hsin Hung Chen, Hsiang Kuang Liang, Wen Sheng Huang, Hong Ming Liu, Chun Wei Wang, Daniel Quah Song Chiek, Kuan Hsuan Chen, Koji Ono, Chun Fu Lin, Jen Kun Chen, Hiroki Tanaka, Ping Ching Pai, Chun-Chieh Wang, Yee Chao, Jia Cheng Lee, Tai-Tong Wong, Sanford P.C. Hsu, Shih-Chieh Lin, Jinn Jer Peir, Shueh Chun Liou, Yu Cheng Kuo, Fong In Chou, Ko Han Lin, Yu Mei Kang, Shih Kuan Chen, Chih Chun Wu, Po Shen Pan, Muh Lii Liang, Shih Ming Hsu, Shih Hwa Chiou, Yi Yen Lee, Chih Wei Li, Yi Wei Chen, Feng Chi Chang |
| المصدر: | Biology, Vol 10, Iss 334, p 334 (2021) Biology Volume 10 Issue 4 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Malignant brain tumor, Uptake ratio, Recursive partitioning, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Distribution (pharmacology), Tumor location, Adverse effect, Objective response, lcsh:QH301-705.5, Complete response, T/B ratio, T/N ratio, General Immunology and Microbiology, glioblastoma, radioresistance, lcsh:Biology (General), 030220 oncology & carcinogenesis, BNCT, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery |
| الوصف: | Although boron neutron capture therapy (BNCT) is a promising treatment option for malignant brain tumors, the optimal BNCT parameters for patients with immediately life-threatening, end-stage brain tumors remain unclear. We performed BNCT on 34 patients with life-threatening, end-stage brain tumors and analyzed the relationship between survival outcomes and BNCT parameters. Before BNCT, MRI and 18F-BPA-PET analyses were conducted to identify the tumor location/distribution and the tumor-to-normal tissue uptake ratio (T/N ratio) of 18F-BPA. No severe adverse events were observed (grade ≥ 3). The objective response rate and disease control rate were 50.0% and 85.3%, respectively. The mean overall survival (OS), cancer-specific survival (CSS), and relapse-free survival (RFS) times were 7.25, 7.80, and 4.18 months, respectively. Remarkably, the mean OS, CSS, and RFS of patients who achieved a complete response were 17.66, 22.5, and 7.50 months, respectively. Kaplan–Meier analysis identified the optimal BNCT parameters and tumor characteristics of these patients, including a T/N ratio ≥ 4, tumor volume < 20 mL, mean tumor dose ≥ 25 Gy-E, MIB-1 ≤ 40, and a lower recursive partitioning analysis (RPA) class. In conclusion, for malignant brain tumor patients who have exhausted all available treatment options and who are in an immediately life-threatening condition, BNCT may be considered as a therapeutic approach to prolong survival. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2079-7737 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b668418ec2e146527bc1eb32d5d014 https://www.mdpi.com/2079-7737/10/4/334 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....97b668418ec2e146527bc1eb32d5d014 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20797737 |
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