XEN® Gel Stent for management of chronic open angle glaucoma: A review of the literature
| العنوان: | XEN® Gel Stent for management of chronic open angle glaucoma: A review of the literature |
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| المؤلفون: | Juliette Buffault, Antoine Labbé, Christophe Baudouin |
| المساهمون: | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Hôpital Ambroise Paré [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Journal Français D'Ophtalmologie Journal Français D'Ophtalmologie, Elsevier Masson, 2019, 42 (2), pp.e37-e46. ⟨10.1016/j.jfo.2018.12.002⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, Intraocular pressure, Open angle glaucoma, Minimally invasive glaucoma surgery, genetic structures, medicine.medical_treatment, Glaucoma, Glaucoma Surgery, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Subconjunctival drainage, Filtering Bleb, 03 medical and health sciences, 0302 clinical medicine, Ophthalmology, medicine, Glaucoma surgery, Minimally Invasive Glaucoma Surgery, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, Chronic Open-Angle Glaucoma, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Hyphema, Combined Surgery, business.industry, MIGS, Gel Stent, Stent, Phacoemulsification, medicine.disease, eye diseases, 3. Good health, 030221 ophthalmology & optometry, Solo procedure, sense organs, business, Xen, 030217 neurology & neurosurgery |
| الوصف: | Summary Purpose The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN ® Gel Stent as a solo procedure or in association with phacoemulsification in patients with chronic open angle glaucoma (OAG). Methods We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN ® gel stent. The main outcome measure was IOP reduction at 12 months follow-up. Secondary outcomes were the decrease in glaucoma medications 12 months after surgery, frequency and type of postoperative interventions and complication rate. Results A total of 8 case series published between 2016 and 2018 were included; six were prospective studies, and two were retrospective. There was no randomized controlled trial. The data concerned a total of 958 eyes of 777 patients. The various studies showed a mean IOP at 12 months between 13 and 16 mmHg, which represented an IOP reduction between 25 and 56% (mean: 42%). This decrease was associated with a reduction in glaucoma medications in all studies. The decrease in IOP was significantly greater in XEN® implantation as a stand-alone procedure (44%) than in combined surgery (32%) (P 0.05). Transient hypotony ( choroidal detachment or choroidal folds (1.5%), hyphema (1.9%), bleb leak (1.1%) and shallow anterior chamber (1.1%) were the most frequent complications. As for severe complications, four cases of malignant glaucoma (0.4%) and one case of retinal detachment have been reported. In the follow-up period, needling has been required in 32% of cases, and a total of 55 eyes (5.7%) required repeat filtering surgery or cyclodestructive procedure. Conclusion XEN® Gel Stent appears effective for reducing IOP and the number of medications in OAG patients within 1 year postoperatively with an acceptable safety profile. However, vigilant postoperative follow-up and frequent postoperative maneuvers are required. |
| اللغة: | English |
| تدمد: | 0181-5512 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9858ec423c30e6571f615cb69bf14713 https://hal.sorbonne-universite.fr/hal-02305931 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....9858ec423c30e6571f615cb69bf14713 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01815512 |
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