SAT-234 DBP Gene Polymorphisms in Adult and Postmenopausal Women: Association with DBP and Vitamin D Serum Levels

التفاصيل البيبلوغرافية
العنوان: SAT-234 DBP Gene Polymorphisms in Adult and Postmenopausal Women: Association with DBP and Vitamin D Serum Levels
المؤلفون: Thaïs Cristófaro Silva, Karen Oppermann, Poli Mara Spritzer, Betânia Rodrigues dos Santos, Gislaine Casanova, Nathalia Cruz da Costa
المصدر: Journal of the Endocrine Society
بيانات النشر: The Endocrine Society, 2019.
سنة النشر: 2019
مصطلحات موضوعية: medicine.medical_specialty, Endocrinology, Postmenopausal women, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, medicine, Vitamin D and neurology, Reproductive Endocrinology, Reproductive Health throughout the Lifespan, business, Gene
الوصف: Vitamin D binding protein (DBP) is one of regulators of vitamin D serum levels. rs4588 and rs7041 polymorphisms of the DBP gene constitute the genetic basis of the three major isoforms of circulating DBP, called GC1s, GC1f and GC2. We evaluated the association between the rs4588, rs7041, rs2282679 SNPs and of DBP isoforms with DBP and 25(OH)D serum levels and investigated whether these gene variants influence on the presence of vitamin D deficiency in a non-selected women sample. In this cross-sectional study, bio-repository samples of 443 apparently healthy women aged 20 to 72 years were analyzed. Most of the participants were ppostmenopausal (n=359). Sufficient circulating levels of 25(OH)D was considered as ≥20ng/mL and deficiency as
تدمد: 2472-1972
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9863a4cd62c60079bc835052a54f7902
https://doi.org/10.1210/js.2019-sat-234
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....9863a4cd62c60079bc835052a54f7902
قاعدة البيانات: OpenAIRE