Thermogelling chitosan-based polymers for the treatment of oral mucosa ulcers
| العنوان: | Thermogelling chitosan-based polymers for the treatment of oral mucosa ulcers |
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| المؤلفون: | Kun Xue, Xiyu Lai, Zhong Xing Zhang, Yun-Long Wu, Jason Y. C. Lim, Zheng Luo, Xian Jun Loh, Xikui Zhang, David J. Young |
| المصدر: | Biomaterials Science. 8:1364-1379 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Staphylococcus aureus, Cell Survival, Polymers, Biomedical Engineering, Microbial Sensitivity Tests, Drug resistance, Pharmacology, Gingival ulcer, Cell Line, Rats, Sprague-Dawley, Chitosan, chemistry.chemical_compound, In vivo, Escherichia coli, medicine, Animals, Humans, General Materials Science, Oral mucosa, Ulcer, business.industry, Mouth Mucosa, Temperature, Biomaterial, Anti-Ulcer Agents, In vitro, Anti-Bacterial Agents, Rats, medicine.anatomical_structure, chemistry, Toxicity, business, Gels |
| الوصف: | Current treatments for oral mucosa-related ulcers use drugs to relieve pain and promote healing, but rarely consider drug resistance to bacterial infection in the microenvironment of the oral cavity or the prevention of bleeding from gingival mucosa ulcers. We herein report an injectable, thermogelling chitosan-based system to address these concerns. An aqueous solution of chitosan-based conjugates (chitosan-g-poly(N-isopropylacrylamide) [CS-g-PNIPAAM] including 1a [CS-g-PNIPAAM with less PNIPAAM] and 1b [CS-g-PNIPAAM with more PNIPAAM], and chitosan-g-poly(N-isopropylacrylamide)-g-polyacrylamide [CS-g-PNIPAAM-g-PAM] 3) could reversibly form semi-solid gels at physiological temperatures for easy application to oral cavity ulcer sites by injection. The chitosan-based conjugate thermogels prepared could inhibit both Gram-positive and Gram-negative bacteria and the two with higher chitosan and poly(N-isopropylacrylamide) contents (1a and 1b) promoted proliferation of gingival fibroblasts in vitro. These two thermogels also exhibited improved blood clotting in an in vivo rat study. Thermogels 1a and 1b effectively promoted ulcer healing and shortened ulcer healing times in an oral gingival mucosa ulcer model using Sprague Dawley (SD) rats. These thermogels showed no obvious toxicity to the main organs of SD rats undergoing gingival ulcer treatment. These results suggest that this antibacterial biomaterial could be a promising injectable therapeutic agent for the treatment for oral mucosa ulcers. |
| تدمد: | 2047-4849 2047-4830 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987eaed15cfa52ddad93db48b638bff7 https://doi.org/10.1039/c9bm01754b |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....987eaed15cfa52ddad93db48b638bff7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20474849 20474830 |
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