Light and corona: guided-wave readout for coronavirus spike protein–host-receptor binding
| العنوان: | Light and corona: guided-wave readout for coronavirus spike protein–host-receptor binding |
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| المؤلفون: | Xiang-Pei Liu, Zhenhuan Yi, Xinghua Liu, Aleksei M. Zheltikov, Ilya V. Fedotov, Kyle Sower, Tao Peng, S. A. Moiseev, Alexei V. Sokolov, Anatoly A. Svidzinsky, Ekaterina Vlasova, Vsevolod V. Belousov, A. A. Voronin, Marlan O. Scully |
| المصدر: | Optics Letters. 45:5428 |
| بيانات النشر: | Optica Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Optics and Photonics, viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Biosensing Techniques, 02 engineering and technology, Plasma protein binding, Peptidyl-Dipeptidase A, medicine.disease_cause, 01 natural sciences, 010309 optics, Betacoronavirus, Optics, 0103 physical sciences, medicine, Humans, Binding site, skin and connective tissue diseases, Pandemics, Coronavirus, Physics, Binding Sites, Guided wave testing, SARS-CoV-2, business.industry, fungi, COVID-19, virus diseases, Spike Protein, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, Viral evolution, Spike Glycoprotein, Coronavirus, Biophysics, Receptors, Virus, Spike (software development), Angiotensin-Converting Enzyme 2, Coronavirus Infections, 0210 nano-technology, business, Protein Binding |
| الوصف: | We show that waveguide sensors can enable a quantitative characterization of coronavirus spike glycoprotein–host-receptor binding—the process whereby coronaviruses enter human cells, causing disease. We demonstrate that such sensors can help quantify and eventually understand kinetic and thermodynamic properties of viruses that control their affinity to targeted cells, which is known to significantly vary in the course of virus evolution, e.g., from SARS-CoV to SARS-CoV-2, making the development of virus-specific drugs and vaccine difficult. With the binding rate constants and thermodynamic parameters as suggested by the latest SARS-CoV-2 research, optical sensors of SARS-CoV-2 spike protein–receptor binding may be within sight. |
| تدمد: | 1539-4794 0146-9592 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98908a72ebb396880b677eb1e35e8c0b https://doi.org/10.1364/ol.402897 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....98908a72ebb396880b677eb1e35e8c0b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15394794 01469592 |
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