Acidic chitinase primes the protective immune response to gastrointestinal nematodes
| العنوان: | Acidic chitinase primes the protective immune response to gastrointestinal nematodes |
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| المؤلفون: | Luke Barron, Allen Smith, Kevin W. Bock, Ian N. Moore, Robert W. Thompson, Lori Fitz, Thomas A. Wynn, Rafael de Queiroz Prado, Sandra White, Lee A. Borthwick, Kevin M. Vannella, Allen W. Cheever, Kevin M. Hart, Margaret M. Mentink-Kane, Thirumalai R. Ramalingam, Joshua Sciurba, Joseph F. Urban |
| المصدر: | Nature Immunology. 17:538-544 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Immunology, Gene Expression, Inflammation, Article, Host-Parasite Interactions, 03 medical and health sciences, Immune system, Chloride Channels, Lectins, parasitic diseases, Hypersensitivity, medicine, Animals, Immunology and Allergy, Helminths, Nippostrongylus, Lung, Strongylida Infections, Mice, Knockout, Nematospiroides dubius, Physiological function, Interleukin-13, biology, Reverse Transcriptase Polymerase Chain Reaction, Chitinases, Immunity, Flow Cytometry, Acquired immune system, beta-N-Acetylhexosaminidases, Gastrointestinal Tract, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Microscopy, Fluorescence, Hormones, Ectopic, Chitinase, biology.protein, Intercellular Signaling Peptides and Proteins, medicine.symptom |
| الوصف: | Acidic mammalian chitinase (AMCase) is known to be induced by allergens and helminths, yet its role in immunity is unclear. Using AMCase-deficient mice, we show that AMCase deficiency reduced the number of group 2 innate lymphoid cells during allergen challenge but was not required for establishment of type 2 inflammation in the lung in response to allergens or helminths. In contrast, AMCase-deficient mice showed a profound defect in type 2 immunity following infection with the chitin-containing gastrointestinal nematodes Nippostrongylus brasiliensis and Heligmosomoides polygyrus bakeri. The impaired immunity was associated with reduced mucus production and decreased intestinal expression of the signature type 2 response genes Il13, Chil3, Retnlb, and Clca1. CD103(+) dendritic cells, which regulate T cell homing, were also reduced in mesenteric lymph nodes of infected AMCase-deficient mice. Thus, AMCase functions as a critical initiator of protective type 2 responses to intestinal nematodes but is largely dispensable for allergic responses in the lung. |
| تدمد: | 1529-2916 1529-2908 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989634e04e0f43c25b89d95e98a70bcb https://doi.org/10.1038/ni.3417 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....989634e04e0f43c25b89d95e98a70bcb |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15292916 15292908 |
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